Results 81 to 90 of about 9,042,320 (297)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

El consumo de drogas y su tratamiento desde la perspectiva de familiares y amigos de consumidores en Bogotá, Colombia Consumo de drogas e seu tratamento, a partir da perspectiva da família e amigos dos consumidores, em Bogotá, Colômbia Drug use and treatment from the perspective of the users' family and friends in Bogota, Colombia

Revista Latino-Americana de Enfermagem, 2009
En este estudio, se presenta el análisis parcial de los resultados de un trabajo cuantitativo, relacionado con la perspectiva que tienen los familiares y amigos de consumidores frente al tratamiento para los problemas derivados del consumo de drogas ...
Daniel Gonzalo Eslava Albarracín, Bruna Brands, Edward Adlaf, Norman Giesbrecht, Laura Simich, Maria da Gloria Miotto Wright   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

TERAPIAS ALTERNATIVAS DE SAÚDE X ALOPATIA: TENDÊNCIAS ENTRE ACADÊMICOS DE MEDICINA

Revista Eletrônica de Enfermagem, 2001
ALTERNATIVE HEALTH THERAPIES VERSUS ALLOPATHY: TENDENCIES AMONG MEDICAL STUDENTS. Influenced by the Cartesian-Newtonian paradigm, medical theories are based on the biomedical pattern of health assistance, where the individual is not seen as being part ...
Lourdes Maria Silva Andraus, Joaquim Tomé de Souza, Ruth Minamisawa Faria, Lizete Malagoni de Almeida Cavalcante Oliveira, Maria Márcia Bachion, Andiara Pereira Martins Fonseca, Maria Alves Barbosa   +6 more
doaj  

Beyond gluten-free diet: a critical perspective on phase 2 trials on non-dietary pharmacological therapies for coeliac disease

Frontiers in Nutrition
Coeliac disease is an immune-mediated chronic enteropathy, with a prevalence of around 1% in the general population and occurring in genetically susceptible individuals after the ingestion of gluten proteins present in wheat, rye and barley. Currently, a
Davide Scalvini, Chiara Scarcella, Giulia Mantica, Erica Bartolotta, Stiliano Maimaris, Erica Fazzino, Federico Biagi, Federico Biagi, Annalisa Schiepatti, Annalisa Schiepatti   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Transtornos mentais comuns e o uso de práticas de medicina complementar e alternativa: estudo de base populacional Commom mental disorders and the use of complementary and alternative medicine: population-based survey

Jornal Brasileiro de Psiquiatria, 2008
OBJETIVO: Verificar a prevalência do transtorno mental comum (TMC) na população da cidade de Montes Claros, MG, e a existência de associação entre os fatores socioeconômicos e a utilização de práticas integrativas e complementares/medicina complementar e
João Felício Rodrigues-Neto, Maria Fernanda Santos Figueiredo, Anderson Antônio de Silveira Faria, Marise Fagundes   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source