Results 111 to 120 of about 87,604,756 (316)
Confronting the bias towards animal experimentation (animal methods bias)
Frontiers in Drug DiscoveryLaws and policies are in place around the world to promote the replacement and reduction of nonhuman animals in science. These principles are rooted not just in ethical considerations for animals, but also in scientific considerations regarding the ...
Catharine E. Krebs +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
New trends on alternative to animal testings in Japan
Folia Pharmacologica Japonica, 2018 Non-animal alternative test methods have developed in the field of genotoxicity, endocrine disrupter, irritation and skin sensitization, and these are used the safety evaluation of chemical, pesticide, pharmaceutical and cosmetic for regulatory use. For the systemic toxicological endpoints of repeated dose toxicity, carcinogenicity, immunotoxicity and ...
openaire +3 more sources
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
, 2008 To date, studies of inhalation toxicity of air contaminants are restricted to animal experiments, mainly because of difficulties in exposing cell cultures directly to these substances. The increasing demand for assessing inhalation toxicity hazards calls
Otto,C. +12 more
core
The data substrate of exposome intelligence: an interoperability profile for untargeted metabolomics
Frontiers in Artificial IntelligenceUntargeted metabolomics, anchored in high-resolution mass spectrometry, has matured into the central analytical platform of human exposomics. It can capture endogenous biology, diet, drugs, microbial chemistry, environmental contaminants, and their ...
Thomas Hartung, Thomas Hartung
doaj +1 more source
Toxicity testing: the search for an in vitro alternative to animal testing
British Journal of Biomedical Science, 2009 Prior to introduction to the clinic, pharmaceuticals must undergo rigorous toxicity testing to ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive to reduce the number of animals used for this purpose due to concerns such as the lack of concordance seen ...
May, J. E. +4 more
openaire +2 more sources
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Risk assessment in animal welfare - EFSA approach
, 2008 Replacement of the rabbit Draize skin irritation test or the animal photo-irritation test is in course in Europeunder the REACH chemical strategy and the Cosmetics Directive. Various in vitro protocols, including3D skin models, have been assessed.
Barbieri,S. +11 more
core
Incorporating animal alternatives in a training programme in laboratory animal care and use
Through the years, scientists and technicians, within their laboratories, trained individuals new to animal research. In the mid-1980s, new and revised laws/guidelines for animal research, including training, were instituted.
core +1 more source