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Advancing alternative methods to reduce animal testing
ScienceEmerging approaches show promise for regulatory ...
Chad P, Nelson +15 more
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The Johns Hopkins Center for Alternatives to Animal Testing
Toxicological Sciences, 1984The Center strives to develop new non-whole-animal test methodologies based on understanding mechanisms of toxicity of chemicals, consumer products, and drugs for the evaluation of safety. The Center will strive for scientific excellence, and to provide superior methods which will replace existing strategies.
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The new paradigm in animal testing – “3Rs alternatives”
Regulatory Toxicology and PharmacologyRegulatory studies have revolutionised over time. Today, the focus has shifted from animal toxicity testing to non-animal for regulatory safety testing. This move is in line with the international 3Rs (Replacement, Reduction, and Refinement) principle and has also changed the regulator's perspective.
Wen Tsin, Poh, Johnson, Stanslas
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Alternatives to Animals in Toxicity Testing
Scientific American, 1989A M, Goldberg, J M, Frazier
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The use of alternatives to animal tests in developing countries.
Developments in biological standardization, 1999Consideration of alternative methods for animal tests in developing countries is important because good quality laboratory animals and proper animal facilities are not always sufficiently available to perform the currently required quality control tests.
Hong, HA, Hendriks, J
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Welcome Alternatives to Animal Testing
Genetic Engineering & Biotechnology News, 2021Gary Michelson, Aysha Akhtar
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Human skin equivalent as an alternative to animal testing.
GMS Krankenhaushygiene interdisziplinar, 2008The 3-D skin equivalent can be viewed as physiologically comparable to the natural skin and therefore is a suitable alternative for animal testing. This highly differentiated in vitro human skin equivalent is used to assess the efficacy and mode of action of novel agents.
Mertsching, H +3 more
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Alternatives to ocular irritation testing in animals.
Lens and eye toxicity research, 1993The preliminary conclusions of a survey of possible non-animal alternatives to the Draize rabbit eye irritancy test, recently conducted for the Commission of the European Communities, are presented. The various types of alternatives to animal tests are reviewed in terms of their current state of development and validation, and also their potential in ...
K A, Atkinson +3 more
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