Results 81 to 90 of about 87,604,756 (316)
AI snake oil? A risk/benefit analysis for toxicology
Frontiers in Artificial IntelligenceArtificial intelligence (AI) is increasingly used to support predictive, mechanistic, and human-relevant toxicology at scale. However, its integration into regulatory science - particularly in drug development - remains uneven, because encouraging ...
Thomas Hartung +5 more
doaj +1 more source
Giving meaning to alternative methods to animal testing
ALTEX, 2018 The 3 rd edition of the advanced theoretical-training course “ Giving meaning to alternative methods to animal testing ” was held in Genoa on July 6-7, 2017. The theoretical modules included talks by specialists from companies engaged in the field of advanced in vitro technologies, who offered participants the possibility to try out their technologies ...
Scanarotti C +7 more
openaire +3 more sources
, 2020 A number of initiatives in Europe, North America and at the OECD over the last 20 years have played a significant role in accelerating the use of alternatives to animals for regulatory toxicity testing, including in silico techniques.
K. Taylor, L. R. Alvarez
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
All things are active … new approach methods for excipient safety
Frontiers in PharmacologyExcipients make up the majority of most medicines by mass, yet they are still called “inactive,” still largely qualified against a 2005 guidance, and still assessed product by product with animal studies that answer the wrong questions.
Thomas Hartung, Thomas Hartung
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
, 2008 The development of the nervous system is a rather complex process known to be affected by different drugs and chemicals. Therefore, regulatory test guidelines have been adopted for the prediction and assessment of developmental neurotoxicity (U.S.EPA ...
Slawik,B. +6 more
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Next generation validation for next generation risk assessment
Frontiers in ToxicologyNext generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro methods, are increasingly inadequate ...
Karolina Kopańska +5 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Animal Testing in Infectiology /
, 2001 Animal testing has a long history, and the resulting knowledge has brought about a significant contribution to the improvement of health and welfare of mankind and animals. Federal regulations concerning the performance of animal testing have become more
Schmidt, A.
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