Effect of Autoclaving on the Physicochemical Properties and Biological Activity of Aluminum Oxyhydroxide Used as an Adjuvant in Vaccines [PDF]
Molecules, 2023 The long-term biodistribution of non-biodegradable microstructures or nanostructures used in vaccinations is widely unknown. This is the case for aluminum oxyhydroxide, the most widely used vaccine adjuvant, which is a nanocrystalline compound that ...
Sofiane Fatmi +2 more
exaly +4 more sources
Structure and compositional analysis of aluminum oxyhydroxide adsorbed pertussis vaccine [PDF]
Computational and Structural Biotechnology Journal, 2021 Purpose: The goal of this study was to characterize an acellular pertussis vaccine (Tdap) containing genetically modified pertussis toxin (gdPT) and TLR agonist adsorbed to AlOOH adjuvant. Methods: Several analytical tools including nanoDSF, FTIR, and LD
Jessica Duprez +7 more
doaj +4 more sources
Mechanistic elucidation of freezing-induced surface decomposition of aluminum oxyhydroxide adjuvant [PDF]
iScience, 2022 Summary: The freezing-induced aggregation of aluminum-based (Alum) adjuvants has been considered as the most important cause of reduced vaccine potency.
Jiahuan Li +14 more
doaj +4 more sources
Nanostructured Aluminum Oxyhydroxide—A Prospective Support for Functional Porphyrin-Based Materials [PDF]
International Journal of Molecular Sciences, 2023 A method for the grafting of unsymmetrical A2BC-type 5,15-bis(4-butoxyphenyl)-10-(4-carboxyphenyl)-20-(phenanthrenoimidazolyl)-porphyrin onto the surface of nanostructured aluminum oxyhydroxide modified with a single SiO2 layer (NAOM) was successfully developed.
Aslan Tsivadze +2 more
exaly +4 more sources
Engineering the hydroxyl content on aluminum oxyhydroxide nanorod for elucidating the antigen adsorption behavior [PDF]
npj Vaccines, 2022 The interaction between the aluminum salt-based adjuvants and the antigen in the vaccine formulation is one of the determining factors affecting the immuno-potentiation effect of vaccines.
Ge Yu +10 more
doaj +4 more sources
One-dimensional nanowires of pseudoboehmite (aluminum oxyhydroxide γ-AlOOH) [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Pseudoboehmite (PB) is a poorly crystallized variant of boehmite, but its crystal structure and morphology have not been clearly understood. In particular, PB gel crystals are formed in an aqueous solution, so the interface between the crystalline surface and water is of crucial importance for understanding its properties
, Takashi Yumura, Iijima Sumio
exaly +5 more sources
Sorbents based on xerogels of zirconium, aluminum and manganese oxyhydroxides [PDF]
Trudy Odesskogo Politehničeskogo Universiteta, 2016 The actual problem of water supply in the world and in Ukraine, in particular, is a high level of pollution in water resources and an insufficient level of drinking water purification.
R.V. Smotraiev +3 more
doaj +8 more sources
Advances on the early cellular events occurring upon exposure of human macrophages to aluminum oxyhydroxide adjuvant [PDF]
Scientific Reports, 2023 Aluminum compounds are the most widely used adjuvants in veterinary and human vaccines. Despite almost a century of use and substantial advances made in recent decades about their fate and biological effects, the exact mechanism of their action has been ...
J.-D. Masson +6 more
doaj +2 more sources
Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology. [PDF]
NPJ Vaccines, 2019 AbstractAluminum salts, developed almost a century ago, remain the most commonly used adjuvant for licensed human vaccines. Compared to more recently developed vaccine adjuvants, aluminum adjuvants such as Alhydrogel are heterogeneous in nature, consisting of 1–10 micrometer-sized aggregates of nanoparticle aluminum oxyhydroxide fibers.
Orr MT +12 more
europepmc +4 more sources
Widespread Myalgia and Chronic Fatigue: Phagocytes from Macrophagic Myofasciitis Patients Exposed to Aluminum Oxyhydroxide-Adjuvanted Vaccine Exhibit Specific Inflammatory, Autophagic, and Mitochondrial Responses [PDF]
Toxics(1) Background: Macrophagic myofasciitis (MMF) is an inflammatory histopathological lesion demonstrating long-term biopersistence of vaccine-derived aluminum adjuvants within muscular phagocytic cells. Affected patients suffer from widespread myalgia and
Jean-Daniel Masson +4 more
doaj +2 more sources