Results 111 to 120 of about 3,731,192 (300)

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Alendronate therapy in cyclosporine-induced alveolar bone loss in rats

, 2007
Background and Objective: Cyclosporine A is an immunosuppressive drug that is widely used in organ transplant patients as well as to treat a number of autoimmune conditions. Bone loss is reported as a significant side-effect of cyclosporine A use because
Rossa, C.
core   +1 more source

Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Factors affecting molar root and periodontal hard tissue changes after orthodontic anterior molar closure of missing tooth spaces retrospective explored based on cone-beam computed tomography three-dimensional reconstruction [PDF]

PeerJ
Objective To correlate the molar teeth and their periodontal conditions after orthodontic anterior removal of the molars to close the gap of missing teeth and to provide risk factor analysis and prognostic assessment for the treatment of such cases ...
Yuhao Huang, Jinglan Zhang, Tianwei Lin, Hong Ai, Ding Bai, Zhihui Mai   +5 more
doaj   +2 more sources

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Alveolar bone loss induced by high alcohol consumption in rats

, 2017
Objective: The aim of the present study was to assess the effect of regular and constant long-term alcohol consumption on the percentage of the remaining periodontal bone support (PBS) and periodontal bone loss (PBL) in adult rats.
Silva, Alan de Aquino, Vinicius Anéas Rodrigues, Daniela Martins de Souza, Kauê Alberto Pereira, Gonsalves, Vitor Sulz, Vitor Sulz Gonsalves, Claudemir de Carvalho de Carvalho, de Souza, Daniela Martins, Pereira, Kauê Alberto, Alan de Aquino Silva, Rodrigues, Vinicius Anéas [UNESP], de Carvalho, Claudemir, Rodrigues, Vinicius Anéas   +12 more
core   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Accelerated alveolar bone loss in mice lacking interleukin-10.

, 2003
Interleukin-10 regulates pro-inflammatory cytokines, including those implicated in alveolar bone resorption. We hypothesized that lack of interleukin-10 leads to increased alveolar bone resorption.
Scheerens, H., Rennick, D., Fletcher, H., Tatakis, D., Al-Rasheed, A.   +4 more
core  

DS_10.1177_0022034518766874 – Supplemental material for Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss

, 2018
Supplemental material, DS_10.1177_0022034518766874 for Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss by M. Liu, P. Kurimoto, J. Zhang, Q.T. Niu, M. Stolina, P.C.
J. Hesterman (5065535), W.G. Richards (5065523), H. Ke (4232059), P.J. Kostenuik (5065529), P. Kurimoto (5065514), M. Liu (1807210), M.S. Ominsky (5065520), P.C. Dechow (5065526), J.Q. Feng (5065511), M.D. Silva (5065538), Q.T. Niu (5065532), J. Zhang (3783634), M. Stolina (5065517)   +12 more
core   +1 more source