Results 91 to 100 of about 3,529,436 (296)

Evaluation of Periapical Radiolucency and Periodontal Bone Loss of Endodontically Treated Teeth Before and After Orthodontic Treatment Using Cone Beam Computed Tomography

Journal of Pharmacy and Bioallied Sciences
Background: The impact of using orthodontic therapy on the periapical radiolucency (PR) and alveolar bone loss in teeth that have received endodontic treatment has not been examined in any prior research.
P. Narayana Prasad, Kanika Sharma, Hardeep Kaur, Mohd Amjad Tahseen, Somya Gupta, Shabina Shafi, Mrunal Meshram   +6 more
doaj   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Sclerostin is essential for alveolar bone loss in occlusal hypofunction

Experimental and Therapeutic Medicine, 2016
Bone loss is caused by occlusal hypofunction and is a serious health concern. This is particularly true of tooth loss, which is common in the elderly. However, the cellular and molecular mechanisms underlying bone loss have yet to be fully elucidated.
Yang, Xu, Lufei, Wang, Yao, Sun, Xianglong, Han, Tian, Gao, Xin, Xu, Tian, Chen, Xuefeng, Zhao, Huan, Zeng, Yanmin, Wang, Ding, Bai   +10 more
openaire   +3 more sources

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Morphometric evaluation of horizontal alveolar bone loss.

, 2014
(A) Representative ApoE−/− mouse left maxilla with BA showing palatal horizontal bone loss area by morphometry (n = 3–5, magnification-10X). The outline represents the area of horizontal alveolar bone resorption (mm2). M1, M2, M3 are molars.
Alexandra R. Lucas (132316), Liying Liu (132271), Erbin Dai (132276), Sasanka Chukkapalli (651199), Hao Chen (5190), Irina Velsko (651197), Raj K. Verma (492730), Mercedes Rivera (651196), Sriram Ambadapadi (651198), Sheela Kesavalu (651195), Lakshmyya Kesavalu (538161)   +10 more
core   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Levels of Cadmium in Human Mandibular Bone

Toxics, 2019
Cadmium (Cd) is an environmental toxicant that accumulates in bone and alters bone turnover and metabolism. Periodontal disease is characterized by tooth loss and tissue destruction, specifically, loss of supporting bone around the teeth.
Andrew W. Browar, Landon L. Leavitt, Walter C. Prozialeck, Joshua R. Edwards   +3 more
doaj   +1 more source

Radiographic evaluation of the effect of obesity on alveolar bone in rats with ligature-induced periodontal disease

, 2013
Cassiane Merigo do Nascimento,1 Tiago Cassol,2 Fernanda Soares da Silva,3 Maria Lucia Bonfleur,4 Carlos Augusto Nassar,5 Patricia Oehlmeyer Nassar5 1Biologica Science and Health Center, State University of West Paraná (UNIOESTE), Cascavel, Paran ...
da Silva FS, Bonfleur ML, Nassar CA, Nassar PO, do Nascimento CM, Cassol T   +5 more
core  

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source