Results 161 to 170 of about 368,637 (232)

Progress in Biomimetic Microdevices for Anticancer Drug Screening and their Potential for Enhancing In Vivo Efficacy

Advanced NanoBiomed Research, EarlyView.
Biomimetic microdevices are redefining anticancer drug screening by mimicking complex tumor microenvironments. This review highlights advances in microfluidic systems, cell microarrays, and in vivo‐like models, offering new insights into drug efficacy prediction and personalized medicine. The development of effective anticancer drugs remains a critical
Ching‐Te Kuo, Yen‐Tzu Liao, Hsinyu Lee   +2 more
wiley   +1 more source

Hyperpolarization Modulation of the T‐Type hCav3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects

Angewandte Chemie, EarlyView.
Human synenkephalin [1–53] (hSYN), an analogue peptide of shrew saliva neurotoxins, was synthesized and its structural characteristics studied. Synthetic hSYN potently activated the T‐type voltage‐gated Ca channel hCav3.2 but did not paralyze mealworms. These findings offer new insight into neurological disorder treatment and evolutionary mechanisms of
Ryo Fukuoka, Yusuke Yano, Nozomi Hara, Chihiro Sadamoto, Andres D. Maturana, Masaki Kita   +5 more
wiley   +2 more sources

Early detection of Alzheimer's disease using deep learning methods. [PDF]

Alzheimers Dement
Mmadumbu AC, Saeed F, Ghaleb F, Qasem SN.   +3 more
europepmc   +1 more source

Multiple and Alternative Sites Make Tau Protein an Adaptable Sticky Surface for the SH3 Domain of Fyn Kinase

Angewandte Chemie, EarlyView.
An NMR‐based study, combined with computational, calorimetric and in‐cell FRET methods, sheds light on the complex recognition mechanism between the intrinsically disordered protein Tau and the SH3 domain of Fyn kinase, highlighting how the multiple binding sites present in Tau make the protein an adaptable recognition surface that can function even ...
Roberto Tira, Giulia Leo, Laura Prandini, Carlo Giorgio Barracchia, Mariapina D'Onofrio, Luca Mollica, Stefano Capaldi, Michael Assfalg, Francesca Munari   +8 more
wiley   +2 more sources

Global multi-specialty clinician perspectives on the implementation of Alzheimer's disease blood biomarkers. [PDF]

Alzheimers Dement
Rodda J, Kuchenbecker LA, Borelli WV, DeMarco ML, Castilhos RM, Cawston EE, Chabrashvili T, Budelier MM, Duran-Aniotz C, Udeh-Momoh C, Akman-Anderson L, Mielke MM, Pereira AC, Algeciras-Schimnich A, Keshavan A.   +14 more
europepmc   +1 more source

Antiparallel β‐Sheet as a Key Motif of Amyloid‐β Inhibitor Designed via Topological Peptide Reprogramming

Angewandte Chemie, EarlyView.
Targeting Amyloid‐β (Aβ) aggregation requires a peptide‐based approach that accounts for the structural heterogeneity of Aβ. Here, we employ topological reprogramming via disulfide bonds to stabilize antiparallel β‐sheets within the dimeric peptide.
Dongjoon Im, Ye Eun Lee, Gyusub Yoon, William A. Goddard III, Tae Su Choi, Hugh I. Kim   +5 more
wiley   +2 more sources

The genetic landscape of early-onset Alzheimer's disease in China. [PDF]

Alzheimers Dement
Qin W, Li FY, Liu WY, Li Y, Cao SM, Wei YP, Li Y, Wang Q, Wang QG, Jia JP.   +9 more
europepmc   +1 more source

N‐Insertion of Diazonium Salts Into Ketone Derivatives

Angewandte Chemie, EarlyView.
Diazonium salts insert into ketones and their silyl enol ethers through a sequence of α‐azenylation and ring expansion via an N‐iminoaziridinium species. Coupled with an efficient N‐N bond cleavage, this protocol offers a mild alternative to Beckmann rearrangements and a powerful tool for skeletal editing of ketones.
Mohammed Anif Pasha, Jiwon Jang, Youngjin Bae, Seunghoon Shin   +3 more
wiley   +2 more sources

Bacteria in the brain: do they have a role in the pathogenesis of Alzheimer's disease? [PDF]

Curr Opin Psychiatry
Bhattacharya A, Shepherd C, El-Assaad F, Mather KA.   +3 more
europepmc   +1 more source