Results 201 to 210 of about 9,392,963 (368)

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Practice parameter: Risk of driving and Alzheimer’s disease (an evidence-based review) [RETIRED] [PDF]

, 2000
Richard Dubinsky, Anthony C. Stein, Kelly E. Lyons   +2 more
openalex   +1 more source

M2 Macrophage‐Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1hi Neutrophils to Enhance Inflamed Bone Regeneration

Advanced Science, EarlyView.
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao, Yijia Yin, Fangyuan Shuai, Waishan Lam, Tao Zhou, Yaxin Xie, Xuesong He, Xianglong Han   +7 more
wiley   +1 more source

Decreased Protein Levels of Nicotinic Receptor Subunits in the Hippocampus and Temporal Cortex of Patients with Alzheimer’s Disease [PDF]

, 2000
Zhi‐Zhong Guan, Xiao Zhang, Rivka Ravid, Agneta Nordberg   +3 more
openalex   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Cell, 2017
Hadas Keren-Shaul, A. Spinrad, A. Weiner, O. Matcovitch-Natan, Raz Dvir-Szternfeld, Tyler K. Ulland, Eyal David, K. Baruch, David Lara-Astaiso, Beáta Tóth, S. Itzkovitz, M. Colonna, M. Schwartz, I. Amit   +13 more
semanticscholar   +1 more source

Alistipes senegalensis is Critically Involved in Gut Barrier Repair Mediated by Panax Ginseng Neutral Polysaccharides in Aged Mice

Advanced Science, EarlyView.
An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang, Hui Wang, Yingna Li, Jing Lu, Xiaolei Tang, Dan Yang, Manying Wang, Daqing Zhao, Fangbing Liu, Shuai Zhang, Liwei Sun   +10 more
wiley   +1 more source

Alteration of Transcription Factors NF-κB and STAT1 in Alzheimer’s Disease Brains

, 1998
Takashi Taniguchi, Yoshihisa Kitamura, Shun Shimohama, Takashi Ota, Yasuji Matsuoka, Yasuyuki Nomura   +5 more
openalex   +1 more source

BrainFusion: a Low‐Code, Reproducible, and Deployable Software Framework for Multimodal Brain‒Computer Interface and Brain‒Body Interaction Research

Advanced Science, EarlyView.
BrainFusion is a low‐code software framework for multimodal brain–computer interface (BCI)​​ and brain–body interaction research. It supports ​electroencephalography (EEG)​, functional near‐infrared spectroscopy (fNIRS), electromyography (EMG)​, and electrocardiography (ECG)​​ integration with standardized preprocessing, feature fusion, and model ...
Wenhao Li, Chenyang Gao, Zhaobo Li, Yunheng Diao, Jiaxin Li, Jiayi Zhou, Jing Zhou, Ying Peng, Guanchu Chen, Xuecheng Wu, Kai Wu   +10 more
wiley   +1 more source

Cl--ATPase in the brain of Alzheimer’s disease

, 1998
Naoki Hattori, Kaori Kitagawa, Toshiaki Higashida, Shun Shimohama, Chiyoko Inagaki   +4 more
openalex   +1 more source