Results 201 to 210 of about 9,650,018 (348)

TVB C++: A Fast and Flexible Back‐End for The Virtual Brain

Advanced Science, EarlyView.
TVB C++ is a streamlined and fast C++ Back‐End for The Virtual Brain (TVB), designed to make it as flexible as TVB, and FAST. Another pillar is to be fully compatible with TVB so easy bindings can be created from Python. Users can easily configure TVB C++ to execute the same code but with enhanced performance and parallelism.
Ignacio Martín, Gorka Zamora‐López, Jan Fousek, Michael Schirner, Petra Ritter, Viktor Jirsa, Gustavo Deco, Gustavo Patow   +7 more
wiley   +1 more source

Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction

, 2022
Michael Kunle Ajenikoko, Abayomi Oyeyemi Ajagbe͓, Oluwanisola Onigbinde, Akeem Ayodeji Okesina, Ahmad Adekilekun Tijani   +4 more
openalex   +1 more source

Early epigenetic changes of Alzheimer’s disease in the human hippocampus [PDF]

, 2020
Idoia Blanco‐Luquin, Blanca Acha, Amaya Urdánoz‐Casado, Javier Sánchez‐Ruiz de Gordoa, Janire Vicuña‐Urriza, Miren Roldán, Alberto Labarga, María Victoria Zelaya, Carolina Cabello, Iván Méndez-López, Maite Mendióroz   +10 more
openalex   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer’s Disease Model [PDF]

, 2016
Yang Shen, Min Tian, Yuqiong Zheng, Fei Gong, Amy K.Y. Fu, Nancy Y. Ip   +5 more
openalex   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

Neuroinflammation in Alzheimer's disease

Lancet Neurology, 2015
M. Heneka, M. Carson, J. E. Khoury, G. Landreth, F. Brosseron, D. Feinstein, A. Jacobs, T. Wyss-Coray, T. Wyss-Coray, J. Vitorica, R. Ransohoff, K. Herrup, S. Frautschy, B. Finsen, Guy C. Brown, A. Verkhratsky, A. Verkhratsky, A. Verkhratsky, K. Yamanaka, J. Koistinaho, E. Latz, E. Latz, A. Halle, G. Petzold, T. Town, D. Morgan, M. Shinohara, V. Perry, C. Holmes, C. Holmes, N. Bazan, D. Brooks, S. Hunot, B. Joseph, N. Deigendesch, O. Garaschuk, E. Boddeke, C. Dinarello, J. Breitner, G. Cole, D. Golenbock, M. Kummer   +41 more
semanticscholar   +1 more source

NARFL Knockout Triggers Ferroptosis‐Driven Vascular Endothelial Dysfunction

Advanced Science, EarlyView.
NARFL is vital for CIA and oxidative stress resistance. NARFL deletion in HPMEC cells, zebrafish, and mice is lethal and rescued by a Ferroptosis inhibitor. NARFL deficiency disrupted its interaction with CIA proteins, decreased aconitase activity, increased IRP1 activity, induced Fe overload, and led to ferroptosis and oxidative stress, resulting in ...
Hui Hu, Jing Luo, Li Yu, Daoxi Qi, Boyu Li, Yating Chen, Chen Wang, Xiaokang Zhang, Wenzheng Guo, Qiyong Lou, Gang Zhai, Yonglin Ruan, Jianfei Huang, Shengchi Shi, Zhan Yin, Fang Zheng   +15 more
wiley   +1 more source

Dietary Neuroketotherapeutics for Alzheimer’s Disease: An Evidence Update and the Potential Role for Diet Quality [PDF]

, 2019
Matthew K. Taylor, Russell H. Swerdlow, Debra K. Sullivan   +2 more
openalex   +1 more source

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Alzheimer's & Dementia, 2011
R. Sperling, P. Aisen, L. Beckett, D. Bennett, S. Craft, A. Fagan, T. Iwatsubo, C. Jack, J. Kaye, T. Montine, Denise C. Park, E. Reiman, C. Rowe, E. Siemers, Y. Stern, K. Yaffe, M. Carrillo, B. Thies, M. Morrison‐Bogorad, M. Wagster, C. Phelps   +20 more
semanticscholar   +1 more source