Results 251 to 260 of about 709,465 (344)

TargetingGSK-3β to Modulate the Wnt Pathway:A Promising Neuroprotective Strategy for Alzheimer’s Disease

Sai Varshini Magham (22438771), Shanooja Shanavas (14424841), Satya Sesha Sai Kiran S. Pindiprolu (22438774), Krishnaveni Nagappan (11359616), Shubhangi More (22438777), Debajit Chaudhury (14295501), Aishwarya Reddy Ramakkamma (22438780), Madhu Tanya Singh (22438783), Ashish Wadhwani (688603), Bipasha Bose (243975), Praveen Thaggikuppe Krishnamurthy (22438786)   +10 more
openalex   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Research on the mechanism and application of plant essential oils in improving Alzheimer’s disease [PDF]

Zhihao Wang, Dong Yang, Song Zhang, Tian Li, Qiulin Yue, Xin Sun, Baojun Li, Kunlun Li, Zhao Chen, Le Su, Lin Zhao   +10 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Molecular Neurodegeneration
Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito   +12 more
doaj   +1 more source

Mixed Pathology and Alzheimer’s Disease

L. Kirazov, M. Dimitrova
openalex   +1 more source

MRI in the Clinical Management of Alzheimer’s Disease: from Early Detection To Therapy Guidance [PDF]

Morelli Chiara, Tarantino Francesca, Raspo Andrea, Saccente Domenico, Rescigno Marco, Galasso Barbara, Laera Marika, Rubini Dino, Pisani Antonio Rosario, Maggialetti Nicola, Stabile Ianora Amato Antonio   +10 more
openalex   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies [PDF]

, 2019
Bateman, Randall J, Benzinger, Tammie L.S., et al,, Flores, Shaney, Gordon, Brian A, Hornbeck, Russ C, Joseph-Mathurin, Nelly, McDade, Eric, Morris, John C, Snider, Barbara J, Speidel, Benjamin, Vlassenko, Andrei G, Wang, Guoqiao, Xiong, Chengjie   +13 more
core   +1 more source