Results 251 to 260 of about 9,650,018 (348)

Pathways towards and away from Alzheimer's disease

Nature, 2004
M. Mattson
semanticscholar   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Oral Exposure to Food‐Grade Nanoparticles Poses a Risk of Alzheimer's Disease‐Like Symptoms by Triggering Autophagy Defects in Neurons

Advanced Science, EarlyView.
Three food‐grade nanomaterials induce dysregulated RyR‐Ca2+ signaling through epigenetic modifications. This dysregulation impairs the autophagic clearance process, ultimately leading to abnormal Aβ deposition and increase phosphorylated tau levels.
Jiaxin Shang, Jun Yan, He Lou, Xuanxi Jiang, Ziyue Wang, Yue Gao, Xiaohui Fan, Xiaoyan Lu   +7 more
wiley   +1 more source

Variant of TREM2 associated with the risk of Alzheimer's disease.

New England Journal of Medicine, 2013
Thorlákur Jónsson, H. Stefánsson, S. Steinberg, I. Jónsdóttir, Pálmi V. Jónsson, J. Snaedal, Sigurbjorn Bjornsson, J. Huttenlocher, A. Levey, J. Lah, D. Rujescu, H. Hampel, I. Giegling, O. Andreassen, K. Engedal, I. Ulstein, S. Djurovic, C. Ibrahim-Verbaas, A. Hofman, M. Ikram, C. V. van Duijn, U. Thorsteinsdóttir, A. Kong, K. Stefánsson   +23 more
semanticscholar   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

Lancet Neurology, 2013
C. Jack, D. Knopman, W. Jagust, R. Petersen, M. Weiner, P. Aisen, L. Shaw, P. Vemuri, H. Wiste, S. Weigand, T. Lesnick, V. Pankratz, M. Donohue, J. Trojanowski   +13 more
semanticscholar   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Systemic infections alter cortical transcriptionalsignatures in Alzheimer’s disease

Pegoraro G, MacBean LF, Smith AR, Soanes DM, Smith RG, Imm J, Harvey J, Kouhsar M, Laroche V, Weymouth L, Castanho I, Hide W, Palmer L, Lett DJ, Robinson AC, Woodman N, McDade K, Boche D, Pishva E, Lunnon K.   +19 more
europepmc   +1 more source

Organelle abnormalities in Alzheimer's disease. [PDF]

Organelle
Gao J, Vicuna L, Wang X.
europepmc   +1 more source