Results 271 to 280 of about 9,650,018 (348)
The neuroprotective promise of semaglutide for Alzheimer's disease. [PDF]
Ann Med Surg (Lond)Hamdar H.
europepmc +1 more source
Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome
Advanced Science, EarlyView.This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha +11 more
wiley +1 more source
Advanced Science, EarlyView.TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han +10 more
wiley +1 more source
Advanced Science, EarlyView.A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai +12 more
wiley +1 more source
Advanced Science, EarlyView.Metabolomics‐based ageing clocks developed using blood biomarkers from over 215 000 European adults, improved the prediction of 10‐year all‐cause mortality compared to traditional models. Biological age acceleration is associated with higher mortality risk, as each additional year of metabolic age corresponded to at least 8% increased risk. These tools
Lei Peng +4 more
wiley +1 more source