Results 291 to 300 of about 709,465 (344)
A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress
Advanced Science, EarlyView.The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract
Alzheimer's disease (AD) Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar +7 morewiley +1 more sourceTargeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity
Advanced Science, EarlyView.Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.Nicolas Marzolini, Taylor V. Brysgel, Ryan J. Rahman, Eno‐Obong Essien, Saw Y. Nwe, Jichuan Wu, Aparajeeta Majumder, Manthan N. Patel, Sachchidanand Tiwari, Carolann L. Espy, Fengyi Dong, Sabrina A. Santos‐De León, Anit Shah, Vladimir V. Shuvaev, Elizabeth D. Hood, Liam S. Chase, Drew Weissman, Jeremy B. Katzen, David B. Frank, Mariko L. Bennett, Oscar A. Marcos‐Contreras, Jacob W. Myerson, Vladimir R. Muzykantov, Sahily Reyes‐Esteves, Jacob S. Brenner +24 morewiley +1 more sourceTricetin, a DietaryFlavonoid, Alleviates Neuroinflammationand Promotes Autophagy in Alzheimer’s Disease by Regulatingthe PI3K/Akt/mTOR Signaling Pathway
Xinyuan Wu (1593211), Dan Su (8007), Jiaxin Xu (11526724), Ge Ge (4325986), Yongzhen Zhang (1616953), Bingjian Wu (21085546), Kun Hu (119408), Jie Ren (176083), Hao Yang (328526) +8 moreopenalex +1 more sourceAI‐Driven Acceleration of Fluorescence Probe Discovery
Advanced Science, EarlyView.We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...Xuefeng Jiang, Yanbo Li, Xue Tian, Sen Yang, Ruina Luo, Cenxing Zhou, Yuxuan Liu, Jingying Hu, Sen Feng, Lu Gan, Chongzhao Ran, Kun‐Hsing Yu, Junhan Zhao, Xiao Han, Xuan Zhai, Yuntao Jia, Jiapei Dai, Xiyue Wang, Biyue Zhu +18 morewiley +1 more sourceTargeting of β‑AmyloidPeptide Fibers,a Biomarker of Alzheimer’s Disease, by Designing SpecificallyFunctionalized Iron Oxide Nanoparticles
Gabriel
R. Guerrero Porras (22447944), Adèle Brison (22447947), Anaïs Becker (22447950), Stéphane Le Calvé (22447953), Marie David (22447956), Gilles Ulrich (1619416), Valérie Mazan (9437419), Marc Schmutz (1390262), Alexis Bigo-Simon (19934950), Damien Mertz (2040979), Céline Kiefer (5571422), Alberto Bencomo Martínez (22447959), Chryslaine Rodríguez Tanty (22447962), Alicia M. Díaz García (22447965), Christelle Hureau (1599418), Marquiza Sablón Carrazana (22447968), Sylvie Bégin-Colin (1404466) +16 moreopenalex +1 more source
