Results 181 to 190 of about 530,865 (344)

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Author Correction: In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque. [PDF]

Nat Microbiol
Drobnič T, Cohen EJ, Calcraft T, Alzheimer M, Froschauer K, Svensson S, Hoffmann WH, Singh N, Garg SG, Henderson LD, Umrekar TR, Nans A, Ribardo D, Pedaci F, Nord AL, Hochberg GKA, Hendrixson DR, Sharma CM, Rosenthal PB, Beeby M.   +19 more
europepmc   +1 more source

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

, 1994
Michael P. Vitek, Koushik Bhattacharya, J M Glendening, Edward G. Stopa, Helen Vlassara, Richard Bucala, K Manogue, Anthony Cerami   +7 more
openalex   +1 more source

The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods

Journal of Magnetic Resonance Imaging, 2008
C. Jack, M. Bernstein, Nick C Fox, Paul M. Thompson, G. Alexander, D. Harvey, B. Borowski, P. Britson, Jennifer L Whitwell, C. Ward, A. Dale, J. Felmlee, J. Gunter, D. Hill, R. Killiany, N. Schuff, Sabrina Fox‐Bosetti, Chen Lin, C. Studholme, C. DeCarli, G. Krueger, H. Ward, G. Metzger, K. T. Scott, R. Mallozzi, D. Blezek, J. Levy, J. Debbins, A. Fleisher, M. Albert, R. Green, G. Bartzokis, G. Glover, J. Mugler, M. Weiner   +34 more
semanticscholar   +1 more source

A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

Nature, 2022
Andrew C. Yang, Ryan T. Vest, Fabian Kern, Davis P. Lee, M. Agam, Christina A. Maat, P. M. Losada, Michelle B. Chen, N. Schaum, Nathalie Khoury, A. Toland, Kruti Calcuttawala, Heather Shin, Róbert Pálovics, Andrew Shin, Elizabeth Y. Wang, Jian Luo, D. Gate, W. Schulz-Schaeffer, Pauline Chu, J. Siegenthaler, M. W. Mcnerney, A. Keller, T. Wyss-Coray   +23 more
semanticscholar   +1 more source

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Processing of Alzheimer Aβ-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer Disease

, 1994
Sam Gandy, Paul Greengard
openalex   +1 more source

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

Alzheimer's & Dementia, 2011
R. Sperling, P. Aisen, L. Beckett, D. Bennett, S. Craft, A. Fagan, T. Iwatsubo, C. Jack, J. Kaye, T. Montine, Denise C. Park, E. Reiman, C. Rowe, E. Siemers, Y. Stern, K. Yaffe, M. Carrillo, B. Thies, M. Morrison‐Bogorad, M. Wagster, C. Phelps   +20 more
semanticscholar   +1 more source

Testing for Alzheimer's [PDF]

Nature, 1993
openaire   +3 more sources

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, EarlyView.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source