Results 211 to 220 of about 461,295 (348)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Brain Atrophy Rates in Normal Aging and Alzheimer Disease [PDF]

, 2017
Micki Dexte
openalex   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Revising the ABIDE MCI to dementia prediction model for automated cerebrospinal fluid assays. [PDF]

Alzheimers Dement
van der Veere PJ, van Harten AC, van Maurik IS, Teunissen CE, Barkhof F, Vos SJB, Froelich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Rüther E, Frisoni GB, Spiru L, Freund-Levi Y, Wallin ÅK, Hampel H, Tsolaki M, Kłoszewska I, Mecocci P, Vellas B, Lovestone S, Galluzzi S, Herukka SK, Santana I, Baldeiras I, de Mendonca A, Silva D, Chetelat G, Poisnel G, Visser PJ, Johnson SC, Stormrud E, Hansson O, Palmqvist S, Piñol-Ripoll G, Alzheimer's Disease Neuroimaging Initiative, Berkhof J, van der Flier WM.   +38 more
europepmc   +1 more source

74. AAV Gene Therapy with Cholesterol 24-Hydroxylase for Alzheimer Disease: In Vivo Consequences on Amyloid and Tau Components of the Pathology [PDF]

, 2012

openalex   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Discovery of cerebrospinal fluid biomarkers for different dementias using mass spectrometry-based proteomics. [PDF]

Alzheimers Dement (Amst)
Stokkel ME, Vermunt L, Knol JC, Chiasserini D, Parnetti L, Piersma SR, Pham TV, de Goeij-de Haas RR, Lemstra AW, Pijnenburg YAL, Visser PJ, Tijms BM, Teunissen CE, Jimenez CR.   +13 more
europepmc   +1 more source

380. AAV Gene Therapy with Cholesterol 24-Hydroxylase Reverses Alzheimer Phenotype of APP23 Mouse Model

, 2009

openalex   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

From Lifestyle to Performance in Aging Research. [PDF]

JAR Life
Khachaturian AS.
europepmc   +1 more source