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Clinics in Geriatric Medicine, 2018
Alzheimer disease neuropathology is characterized by the extracellular accumulation of Aβ peptide and intracellular aggregation of hyperphosphorylated tau. With the progression of the disease, macroscopic atrophy affects the entorhinal area and hippocampus, amygdala, and associative regions of the neocortex. The locus coeruleus is depigmented.
Ana Laura, Calderon-Garcidueñas +1 more
openaire +4 more sources
Alzheimer disease neuropathology is characterized by the extracellular accumulation of Aβ peptide and intracellular aggregation of hyperphosphorylated tau. With the progression of the disease, macroscopic atrophy affects the entorhinal area and hippocampus, amygdala, and associative regions of the neocortex. The locus coeruleus is depigmented.
Ana Laura, Calderon-Garcidueñas +1 more
openaire +4 more sources
The Lancet, 2019
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and functional decline associated with age together with a particular neuropathology. It was first described by Alois Alzheimer in 1906 about a patient whom he first encountered in 1901.
Jose A, Soria Lopez +2 more
openaire +4 more sources
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and functional decline associated with age together with a particular neuropathology. It was first described by Alois Alzheimer in 1906 about a patient whom he first encountered in 1901.
Jose A, Soria Lopez +2 more
openaire +4 more sources
Maturitas, 1999
This article reviews the clinical and neuropathological features of Alzheimer's disease, its known genetic and non-genetic risk factors, procedures used to make the diagnosis and rule out other reversible and non-reversible forms of dementia, and the treatment strategies used to help patients and their families cope with the problem.
E M, Reiman, R J, Caselli
openaire +2 more sources
This article reviews the clinical and neuropathological features of Alzheimer's disease, its known genetic and non-genetic risk factors, procedures used to make the diagnosis and rule out other reversible and non-reversible forms of dementia, and the treatment strategies used to help patients and their families cope with the problem.
E M, Reiman, R J, Caselli
openaire +2 more sources
The Lancet, 2016
Although the prevalence of dementia continues to increase worldwide, incidence in the western world might have decreased as a result of better vascular care and improved brain health. Alzheimer's disease, the most prevalent cause of dementia, is still defined by the combined presence of amyloid and tau, but researchers are gradually moving away from ...
Gholamreza Azizi, Abbas Mirshafiey
openaire +5 more sources
Although the prevalence of dementia continues to increase worldwide, incidence in the western world might have decreased as a result of better vascular care and improved brain health. Alzheimer's disease, the most prevalent cause of dementia, is still defined by the combined presence of amyloid and tau, but researchers are gradually moving away from ...
Gholamreza Azizi, Abbas Mirshafiey
openaire +5 more sources
Continuum, 2022
Alzheimer disease (AD) is the most common cause of dementia in adults (mid to late life), highlighting the importance of understanding the risk factors, clinical manifestations, and recent developments in diagnostic testing and therapeutics.Advances in fluid (CSF and blood-based) and imaging biomarkers are allowing for a more precise and earlier ...
openaire +2 more sources
Alzheimer disease (AD) is the most common cause of dementia in adults (mid to late life), highlighting the importance of understanding the risk factors, clinical manifestations, and recent developments in diagnostic testing and therapeutics.Advances in fluid (CSF and blood-based) and imaging biomarkers are allowing for a more precise and earlier ...
openaire +2 more sources
Seminars in Neurology, 2013
Alzheimer's disease (AD) is the most common neurodegenerative cause of dementia and is responsible for significant individual morbidity and mortality, and economic impact on the health care system. Neurodegeneration (including neuronal atrophy and/or loss) are attributed to extraneuronal toxic amyloid oligomers and proteins, intraneuronal ...
Carly, Oboudiyat +4 more
openaire +2 more sources
Alzheimer's disease (AD) is the most common neurodegenerative cause of dementia and is responsible for significant individual morbidity and mortality, and economic impact on the health care system. Neurodegeneration (including neuronal atrophy and/or loss) are attributed to extraneuronal toxic amyloid oligomers and proteins, intraneuronal ...
Carly, Oboudiyat +4 more
openaire +2 more sources
Alzheimer's disease model explains Alzheimer’s disease incidences
Journal of Alzheimer's disease reportsAD-model rationale: The contributing factors of Alzheimer's disease are cerebral vessel disease, insulin resistance, hypometabolism, oxidative stress, abnormal-protein aggregation, and inflammation. Brain insulin resistance is influenced by inflammation,
John Cheung-Yuen Chan
semanticscholar +1 more source
Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?
Nature Reviews Neurology, 2020Fangda Leng, P. Edison
semanticscholar +1 more source
Synaptic degeneration in Alzheimer disease
Nature Reviews Neurology, 2022Makis Tzioras +3 more
semanticscholar +1 more source