Results 71 to 80 of about 118,414 (165)

Europa y América en la revolución geodemográfica

Estudios Demográficos y Urbanos, 2005
El trabajo establece un parangón entre Europa y América tanto de sus vivencias demográficas en el pasado con el Nuevo Mundo, como de las repercusiones futuras de las demografías de ambas regiones en un mundo globalizado. Con diversos indicadores el autor
Massimo Livi Bacci
doaj  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Tocqueville's "Sacred Ark"

Araucaria, 2019
Este artículo explora diversos aspectos constitutivos de la “nueva ciencia de la política” de Tocqueville. Centrado en sus componentes interdisciplinarios, comparativos, normativos y políticos, trata de poner de manifiesto la sofisticación conceptual y ...
Aurelian Craiutu
doaj   +1 more source

Efecto del Patrocinio de la Copa América en las percepciones de Luis Vuitton: una perspectiva internacional

Revista Galega de Economía, 2014
Sobre la base de una amplia revisión de la literatura dedicada a los estudios experimentales sobre los efectos del patrocinio en las percepciones de la marca, en el presente estudio se desarrolla conceptualmente el proceso de persuasión en la actividad de patrocinio.
openaire   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Lições da América: o problema do americanismo em Tocqueville Lessons from America: the problem of americanism in Tocqueville

Lua Nova: Revista de Cultura e Política, 1993
Quem deve prestar lições a quem: a América à Europa ou vice-versa? O autor interpreta o pensamento de Tocqueville à luz dessa questão, trabalhando com o conceito de americanismo - isto é, a conciliação que se tornou possível nos Estados Unidos, sem que rupturas revolucionárias ocorressem, entre estado social de igualdade e liberdade, entre ...
openaire   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

El Siglo de Oro desde una consideración atlántica: Miguel de Cervantes y el Inca Garcilaso

Cuadernos del CILHA
En la actualidad se desarrolla cierto enfoque de la literatura hispánica del Siglo de Oro que pone el acento en las relaciones de coevidad e intercambio entre España y América.
Graciela Maturo
doaj