Results 71 to 80 of about 5,451,349 (285)
El legado de la Real Expedición Filantrópica de la Vacuna (1803-1810): las juntas de vacuna
Asclepio: Revista de Historia de la Medicina y de la Ciencia, 2004 La Expedición de la Vacuna, dirigida por los médicos Francisco Xavier Balmis y José Salvany, es la gesta científica y sanitaria más importante de época colonial.
Susana María Ramírez Martín
doaj +1 more source
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Europa y América en la revolución geodemográfica
Estudios Demográficos y Urbanos, 2005 El trabajo establece un parangón entre Europa y América tanto de sus vivencias demográficas en el pasado con el Nuevo Mundo, como de las repercusiones futuras de las demografías de ambas regiones en un mundo globalizado. Con diversos indicadores el autor
Massimo Livi Bacci
doaj
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Araucaria, 2019 Este artículo explora diversos aspectos constitutivos de la “nueva ciencia de la política” de Tocqueville. Centrado en sus componentes interdisciplinarios, comparativos, normativos y políticos, trata de poner de manifiesto la sofisticación conceptual y ...
Aurelian Craiutu
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Aglomeraciones mineras y desarrollo local en América Latina
, 2001 Incluye BibliografíaPrólogo de Eduardo Chaparro AvilaPrefacio de Cristina EchavarríaPresentación de José Antonio OcampoLa singularidad de este libro radica en la aplicación de los conceptos de la teoría de aglomeraciones (clusters); al análisis de la ...
core
Aging and Cancer, EarlyView.This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho +4 more
wiley +1 more source