Results 51 to 60 of about 118,414 (165)

Científicos americanos en las cortes constituyentes. La cuestión ultramarina

Revista de Indias, 2003
Con este estudio pretendemos contribuir al mayor conocimiento sobre un capítulo poco estudiado de la historia de la ciencia hispanoamericana. Lo haremos a través del seguimiento de las actuaciones como diputados en las Cortes españolas de tres destacados
Jose Luis Maldonado Polo
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

«Como antiguas estatuas de bronce» Sobre la disolución del clasicismo en la relación histórica de un viaje a las regiones equinocciales del nuevo mundo, de Alejandro de Humboldt

Revista de Indias, 2001
La interpretación de América usando motivos clasicistas como modelos imperiales de apropiación, «antiquización», es una de las principales estrategias retóricas en los relatos de viajes de Alejandro de Humboldt.
Oliver Lubrich
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Pandemia-sindemia de la Covid-19 en América al 30/08/2023

Tecnología en Marcha
El presente estudio describe la evolución de la pandemia-sindemia de la Covid-19 en América al 30/08/2023, el cual cubre desde la declaración de la pandemia por parte de la OMS el 11/03/2020, la declaración del fin de la emergencia sanitaria al 06/05 ...
Darner Mora Alvarado
doaj   +1 more source

“Vigencia de la Imagen de Calibán en el Pensamiento Latinoamericano”

Estudios Latinoamericanos, 2015
A partir de una analogía literaria en la obra la tempestad de Shakespeare con su personaje el Calibán se logra explicar la Dialéctica de la Conquista. La imagen del indio expuesta desde el lado oscuro: “la del mal salvaje”.
Sofia Reding Blase
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

A latinidade do conceito de América Latina

Revista Geographia, 2013
De uma maneira geral, assumimos de modo tão naturalizado as designações e os recortes geográficos das regiões que visualizamos em mapas ou que utilizamos como referência de pertencimento e localização, que dificilmente nos questionamos sobre os processos
Pedro de Araújo Quental
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source