Results 121 to 130 of about 1,457,657 (267)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Vicente Sáenz: el antifascismo itinerante o los fantasmas del patriarca
Cuadernos Inter.c.a.mbio sobre Centroamérica y el Caribe, 2012 El artículo explica el papel y la vivencia del intelectual costarricense Vicente Sáenz en la era antifascista, planteando para ello dos hipótesis: que el caso de Sáenz resulta un contrapunto para hacer lectura de la evolución y desenlace del ...
Dennis Arias Mora
doaj
Amílcar Herrera: la ciencia y la tecnología como condición para el desarrollo de América Latina. [PDF]
, 2010 El capítulo presenta una síntesis del pensamiento de Amílcar Herrera, quien enfatizó en su obra la importancia central de la CyT en la superación del atraso de nuestros países; sin embargo, esto no le hacía perder de vista la complejidad que representa ...
Núñez, Ismael
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Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Exploring social innovation in health in Central America and the Caribbean. [PDF]
Rev Panam Salud Publica, 2020 Mothe J +4 more
europepmc +1 more source
A review of the population structure of yellowfin tuna, Thunnus albacares, in the Eastern Pacific Ocean [PDF]
, 1964 ENGLISH: Since its inception in 1950 by agreement between the Republic of Costa Rica and the United States of America, the Inter-American Tropical Tuna Commission has been engaged in studies of the biology, ecology and population dynamics of yellowfin ...
Alverson, Franklin G. +3 more
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
El surgimiento de China: Una visión desde América Central [PDF]
Este estudio trata sobre el impacto del surgimiento de China en las economías centroamericanas, con especial énfasis en Guatemala y Honduras. Generalmente, la temática del impacto de China se la enfoca desde el punto de vista de las amenazas que se ...
Manuel R. Agosin +2 more
core +1 more source
Auge y caída de Teotihuacan, la primera gran ciudad de América [PDF]
, 2014 Teotihuacan ocupa un papel central en América prehispánica. Fue la primera ciudad del continente, y desde ella se difundieron aspectos básicos en urbanismo, arquitectura, economía, arte y religión, que llegaron hasta los aztecas, hechos que todavía ...
Miguel López, Jaime
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