Results 51 to 60 of about 528,244 (265)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Revista de Ciencias Sociales, 2019 En este artículo se propone una definición de las grassroots economies (economías de base) para aproximarse a las estrategias que permiten comprender cómo sobreviven las personas pobres en diferentes períodos históricos.
Ronny J. Viales Hurtado +1 more
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CARMEN LYRA: ESCENARIOS POLÍTICOS, CULTURALES Y SUBJETIVOS EN LA ERA ANTIFASCISTA
Revista de Ciencias Sociales, 2013 El antifascismo en Costa Rica pasó de ser un movimiento contestatario marcado por el vanguardismo intelectual, a un movimiento cívico y nacionalista neutralizado por las alianzas políticas de los años cuarenta. Tal cambio fue posibilitado en parte por la
Dennis F. Arias Mora
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Eje Central Para Avanzar Hacia Un Desarrollo Social Inclusivo
, 2023 Documento preparado por la Comisión Económica para América Latina y el Caribe (CEPAL) para la Quinta Reunión de la Conferencia Regional sobre Desarrollo Social de América Latina y el Caribe, organizada por la CEPAL, el Ministerio de Desarrollo Social y ...
Comisión Económica para América Latina y el Caribe (CEPAL)
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
, 2016 Mollusks fossil communities found is southerm Central America developed in accordance to tectonic, and hence favorable enviromental conditions of the Isthmus evolution.
Aguilar Alvarez, Ana Teresita
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Revista de Ciencias Sociales, 2019 En este estudio se evidencia una abundante inversión estatal a nivel social y productivo en la región Chorotega, que permitió su plena incorporación al modelo económico nacional, con base en el análisis de trayectoria de numerosos datos de planes de ...
Edgar Eduardo Blanco Obando
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source