Results 61 to 70 of about 7,577,728 (211)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Revista de Ciencias Sociales, 2019 En este estudio se evidencia una abundante inversión estatal a nivel social y productivo en la región Chorotega, que permitió su plena incorporación al modelo económico nacional, con base en el análisis de trayectoria de numerosos datos de planes de ...
Edgar Eduardo Blanco Obando
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Occurrence of Aflatoxin M1 in cow milk in El Salvador: Results from a two-year survey
Toxicology Reports, 2018 Aflatoxin M1 (AFM1) is a metabolite of Aflatoxin B1 (AFB1) and is excreted through cow´s milk. AFM1 contamination of milk is extended geographically and there might be seasons-related variations for both prevalence and contents, with higher than average ...
Oscar Peña-Rodas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
“Vías de penetración de la masonería en el Caribe”
REHMLAC, 2009 La introducción y desarrollo de la Fr ancmasonería en América fue un claro refl ejo y transposición de la situación de la masonería en la Europa del siglo XVIII y comienzo s del XIX.
José Antonio Ferrer Benimeli
doaj
Geofísica Internacional, 1989 El archivo de datos de sismicidad compilado por la N.O.A.A. (National Oceanic and Atmospheric Administration) de los Estados Unidos conocido como "Earthquake Data File" o EDF, contiene informacion que puede ser de gran importancia cuando se va a estudiar
F. R. Zuñiga
doaj +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Spatial variations of b-values in the subduction zone of Central America
Geofísica Internacional, 2003 Estudiamos la distribución frecuencia-magnitud a lo largo de la trinchera mesoamericana (MAT), usando 2345 eventos del periodo 1964-1994. Utilizamos el catalogo regional MIDAS con magnitud de completitud de 4.2.
David A. Monterroso, Ota Kulhánek
doaj +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source