Results 61 to 70 of about 528,244 (265)
Revista de Ciencias Sociales, 2017 Desde hace más de una década, el Centro de Investigaciones Históricas de América Central (cihac) de la Universidad de Costa Rica ha desarrollado el estudio de la historia ambiental de Costa Rica y de Centroamérica, en conjunto con el Posgrado ...
Ronny Viales Hurtado
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Las lenguas de América Central y el idioma de sutiava según su documentación por Walter Lehmann
Revista de Historia, 2015 Entre 1907 y 1909, el lingüista alemán Walter Lehmann realizó un viaje de exploración por varios países de América Central. Encargado por los museos antropológicos de Berlín, Hamburgo y Munich, el alumno de Eduard Seler buscó principalmente fuentes ...
Martin Künne
doaj
Revista de Ciencias Sociales, 2017 En este artículo se discuten algunos elementos básicos para la formulación de políticas científicas, en general, para la cohesión social, desde una perspectiva de Ciencia, Tecnología y Sociedad (CTS).
Ronny Viales Hurtado
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Occurrence of Aflatoxin M1 in cow milk in El Salvador: Results from a two-year survey
Toxicology Reports, 2018 Aflatoxin M1 (AFM1) is a metabolite of Aflatoxin B1 (AFB1) and is excreted through cow´s milk. AFM1 contamination of milk is extended geographically and there might be seasons-related variations for both prevalence and contents, with higher than average ...
Oscar Peña-Rodas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Capitalismo dependente e gasto social na América Latina: Brasil e Venezuela no século XXI [PDF]
, 2006 TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Serviço SocialEste trabalho de conclusão de curso consiste em estudo crítico-dialético sobre a magnitude do investimento social em Brasil e Venezuela, tendo em ...
Rocha, Mirella Farias
core
, 2016 In this study are identified and described two fossil shark teeth proceeding from the Lower Miocene of Santa Teresa Formation, at the southern Nicoya Peninsula and San Miguel Formation at the southeast area of the Central Valley, in the central part of ...
Laurito Mora, César Alberto
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