Results 81 to 90 of about 14,795,913 (293)
Revista de Ciencias Sociales, 2019 En este estudio se evidencia una abundante inversión estatal a nivel social y productivo en la región Chorotega, que permitió su plena incorporación al modelo económico nacional, con base en el análisis de trayectoria de numerosos datos de planes de ...
Edgar Eduardo Blanco Obando
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, 2016 For the first time the genus Scirrotherium is recorded and a new species is described for the early Hem- phillian of Costa Rica. This finding constitutes a new clue about the early arrived of South American heralds to Central American during Pre-Great ...
Valerio Zamora, Ana Lucía +1 more
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Revista de Ciencias Sociales, 2017 Desde hace más de una década, el Centro de Investigaciones Históricas de América Central (cihac) de la Universidad de Costa Rica ha desarrollado el estudio de la historia ambiental de Costa Rica y de Centroamérica, en conjunto con el Posgrado ...
Ronny Viales Hurtado
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Revista de Ciencias Sociales, 2017 En este artículo se discuten algunos elementos básicos para la formulación de políticas científicas, en general, para la cohesión social, desde una perspectiva de Ciencia, Tecnología y Sociedad (CTS).
Ronny Viales Hurtado
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Metalogenia de oro y cobre en América central
, 2016 Gold and copper deposits in Central America are hosted by island arc volcanic rocks of Late Cre-taceous and younger age. Low potassium tholeiitic basalts form the base of the volcanic pile and were deposited in an intraoceanic island arc.
Nietzen, Fernando, Nelson, Carlos E.
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Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance
Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah +5 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Occurrence of Aflatoxin M1 in cow milk in El Salvador: Results from a two-year survey
Toxicology Reports, 2018 Aflatoxin M1 (AFM1) is a metabolite of Aflatoxin B1 (AFB1) and is excreted through cow´s milk. AFM1 contamination of milk is extended geographically and there might be seasons-related variations for both prevalence and contents, with higher than average ...
Oscar Peña-Rodas +2 more
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