Results 91 to 100 of about 575,735 (293)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

LOS SISTEMAS DE RELACIONES LABORALES. ANÁLISIS DESDE EL CONO SUR DE AMÉRICA LATINA

Cadernos Prolam/USP, 2011
El objetivo de este documento es construir un marco teórico metodológico para el análisis de los Sistemas de Relaciones Laborales teniendo en cuenta las particularidades de la región.
Jorge Notaro
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Regional drought in the southern of South America: physical aspects Seca regional no sul da América do Sul: aspectos físicos

Revista Brasileira de Meteorologia, 2010
From the indices of monthly and annual climatic drought in six regions in southern South America and their associations with seventeen predictors, the probable physical causes of droughts are analyzed.
Juan Leonidas Minetti, Walter Mario Vargas, Arnobio German Poblete, Maria Elvira Bobba   +3 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Caminhando pelas Ruas de Desterro – Santa Catarina - Brasil

Caminho Aberto: Revista de Extensão do IFSC, 2018
Para atender a demanda da atividade turística e propiciar qualidade no atendimento nos serviços, o projeto Caminhando pelas Ruas de Desterro - SC teve como objetivo oferecer a atividade de educação patrimonial junto a trabalhadores da cidade através de ...
Maria Helena Alemany Soares, Natália Regina Salomão de Freitas, Danielle Manso Muniz Gonçalves   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A aviação comercial na América do Sul: um estudo comparativo entre a influência alemã e norte-americana na região (1919-1945)

Estudos Ibero Americanos, 2003
O presente estudo enfoca o desenvolvimento da aviação na América do Sul entre 1919 e 1945. A disputa entre as potências pela abertura de novos mercados e áreas de influência política e cultural marcaram esse período. O artigo propõe um estudo comparativo
Fay, Cláudia Musa
doaj  

Apresentação

Hoplos, 2019
Em 1º de janeiro de 2003, durante a sessão de posse no Congresso Nacional, o então presidente Luiz Inácio Lula da Silva anunciou que as relações internacionais de seu governo seriam orientadas para “a construção de uma América do Sul politicamente ...
Leandro Gavião
doaj   +1 more source