Results 101 to 110 of about 959,547 (311)

LOS SISTEMAS DE RELACIONES LABORALES. ANÁLISIS DESDE EL CONO SUR DE AMÉRICA LATINA

open access: yesCadernos Prolam/USP, 2011
El objetivo de este documento es construir un marco teórico metodológico para el análisis de los Sistemas de Relaciones Laborales teniendo en cuenta las particularidades de la región.
Jorge Notaro
doaj   +1 more source

Conservação ambiental forte alcançada através de sistemas agroflorestais multiestratificados: 1 - agroflorestas e a restauração ecológica de florestas. [PDF]

open access: yes, 2015
O objetivo deste trabalho foi verificar se um sistema agroflorestal multiestratificado (agrofloresta) agroecológico pode ser considerado como tendo uma sustentabilidade ambiental forte, com base em uma análise dos serviços ecossistêmicos de restauração ...
AMARAL-SILVA, J.   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Ensaios cooperativos - ferrugens do trigo cone sul da América do Sul 1980-1981. [PDF]

open access: yes, 2015
bitstream/item/126504/1/ID-1694 ...
AITA, L., BARCELLOS, A. L.
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Regional drought in the southern of South America: physical aspects Seca regional no sul da América do Sul: aspectos físicos

open access: yesRevista Brasileira de Meteorologia, 2010
From the indices of monthly and annual climatic drought in six regions in southern South America and their associations with seventeen predictors, the probable physical causes of droughts are analyzed.
Juan Leonidas Minetti   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Caminhando pelas Ruas de Desterro – Santa Catarina - Brasil

open access: yesCaminho Aberto: Revista de Extensão do IFSC, 2018
Para atender a demanda da atividade turística e propiciar qualidade no atendimento nos serviços, o projeto Caminhando pelas Ruas de Desterro - SC teve como objetivo oferecer a atividade de educação patrimonial junto a trabalhadores da cidade através de ...
Maria Helena Alemany Soares   +2 more
doaj   +1 more source

Influências Remotas Sobre a Amazônia e dela Sobre Outras Regiões: o Homem, a Flora e a Fauna [PDF]

open access: yes, 1999
A última e maior reserva florestal tropical do planeta que precisa ser conservada e explorada conscientemente, preservando o meio ambiente (desenvolvimento sustentável). Pois sua destruição alterará o clima da América do Sul, principalmente.
Julio Buchmann
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

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