Results 101 to 110 of about 575,735 (293)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Política regional e projeção de interesses privados:

Carta Internacional, 2019
O artigo tem como objetivo discutir o papel da América do Sul na política externa dos governos de Luiz Inácio Lula da Silva (2003-2010). Desenvolve-se ao longo do texto o argumento de que a América do Sul foi o espaço prioritário de articulação da ...
Karen dos Santos Honorio
doaj   +1 more source

Investimentos Chineses em Infraestrutura na América do Sul: impactos sobre a integração regional

, 2017
O artigo objetiva analisar os investimentos chineses em infraestrutura na America do Sul. Analisa-se esse padrao de relacionamento China-America do Sul, os impactos a integracao sul-americana e ao Brasil como lider regional.
Bruna Coelho Jaeger
semanticscholar   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Povoamento inicial da América do Sul: contribuições do contexto brasileiro

Estudos Avançados, 2015
O povoamento inicial da América do Sul não foi um processo homogêneo. Em termos cronológicos, as evidências apontam para a ocupação de diversas regiões já em fins do Pleistoceno e início do Holoceno, com datas anteriores ou ao menos contemporâneas ao ...
Lucas Bueno, Adriana Dias
doaj   +1 more source

Atenção primária integral e sistemas segmentados de saúde na América do Sul

, 2017
The article analyzes recent reforms in primary health care in the South American countries, discussing the scope and challenges for establishing comprehensive primary health care in the region’s health systems.
L. Giovanella, Patty Fidélis de Almeida
semanticscholar   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

CLIMATOLOGIA DE FRENTES FRIAS NA AMÉRICA DO SUL E SUA RELAÇÃO COM O MODO ANULAR SUL (CLIMATOLOGY OF COLD FRONTS OVER SOUTH AMERICA AND ITS RELATION WITH THE SOUTHERN ANNULAR MODE)

, 2015
Este estudo abordou tres objetivos: (1) determinar a climatologia de frentes frias (FFs) em 8 cidades ao longo da costa leste da America do Sul no periodo de 2007 a 2013 com base em analise visual de cartas sinoticas e com um metodo objetivo usando duas ...
Amanda Balbino Cardozo, Igor Stivanelli Custódio, M. Reboita, Sâmia Regina Garcia   +3 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source