Results 31 to 40 of about 16,928 (219)

REGULAÇÕES INSTITUCIONAIS E INTEGRAÇÃO CULTURAL: UM BINÔMIO VIÁVEL

open access: yesCadernos Prolam/USP, 2003
O artigo a seguir explora e enfatiza alguns aspectos da pesquisa de doutorado da autora. Apresenta as formas e princípios organizativos de grupos de Alcoólicos Anônimos no Brasil e no Uruguai, e analisa relações entre suas regulações institucionais e o ...
Eliane Ganev
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

REACTIVACION DE LA INDUSTRIA ARGENTINA, CONCENTRACIÓN, EXTRANJERIZACIÓN Y CRECIENTES DESEQUILIBRIOS COMERCIALES CON BRASIL

open access: yesCadernos Prolam/USP, 2010
El artículo identifica algunos de los principales rasgos que caracterizan la reactivación de la economía y, en especial, de la industria argentina en la posconvertibilidad, a partir del quiebre del régimen de conversión fija con el dólar estadounidense ...
Daniel Aspiazu, Martín Schorr
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Seasonal variation in the number of captures of Artibeus lituratus (Olfers, 1818) and Sturnira lilium (E. Geoffroy, 1810) (Chiroptera: Phyllostomidae) in the upper strata of an Atlantic Forest remnant in southern Brazil

open access: yesBiotemas, 2014
This study aimed to analyze the occurrence of seasonal variations in the number of captures of Artibeus lituratus and Sturnira lilium in the upper strata of an Atlantic Forest remnant in southern Brazil. It was conducted in the town of Pedras Grandes, in
Fernando Carvalho   +2 more
doaj  

A VERSÃO BRASILEIRA DOS DIREITOS HUMANOS. UMA REFLEXÃO POLÍTICA-ANTROPOLÓGICA DOS PNDHS I E II

open access: yesCadernos Prolam/USP, 2005
Este ensaio trata do Plano Nacional de Direitos Humanos – PNDH (I e II), criado no Brasil em sua primeira versão em 1996 e complementado em 1999, durante o governo de Fernando Henrique Cardoso.
Neusa Romero Barazal
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

BUENOS AIRES DANS LES ANNÉS 90: GOUVERNANCE URBAINE DANS UNE MÉTROPOLE DIVISÉE

open access: yesCadernos Prolam/USP, 2003
Que signifie parler de gouvernance urbaine, dans une grande métropole de 12 millions d’habitants qui a vu, dans les années 90, se creuser la coupure entre la ville-centre dopée par la nouvelle économie et les immenses périphéries dévastées par la ...
Marie-France Prévôt Schapira
doaj   +1 more source

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