Results 41 to 50 of about 16,928 (219)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
O Brasil e a distante América do Sul
Revista de História, 2001 Este artigo discute a elaboração de um discurso político original, no Brasil do século XIX, que fundou uma certa interpretação brasileira sobre o mundo hispano-americano, contribuindo para a constituição de um imaginário sobre a outra América, que a ...
Maria Ligia Coelho Prado
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
SISTEMA TRIBUTARIO Y EL PROBLEMA FEDERATIVO: LA EVOLUCIÓN DEL CASO BRASILEÑO
Cadernos Prolam/USP, 2002 El presente artículo tiene por objetivo caracterizar la evolución de los aspectos tributarios de las relaciones intergubernamentales brasileñas. Buscando establecer taxonomías relativas tanto a las distintas posibilidades de evolución histórica de la ...
Amaury Patrick Gremaud
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
POLITICA INDUSTRIAL Y PEQUEÑAS Y MEDIANAS EMPRESAS: EL CASO ARGENTINO
Cadernos Prolam/USP, 2009 Este trabajo examina el caso de las políticas argentinas para las pequeñas y medianas empresas (PyMEs). Se trata de políticas a las que se les reconoce la capacidad de suplir funciones de fomento y de coordinación que los automatismos del mercado no ...
Marina Schenkel
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Cadernos Prolam/USP, 2006 A proposta deste artigo é examinar as singularidades e os desafios enfrentados pela comunidade boliviana que, na busca de melhores condições de vida, submete-se ao tráfico humano e ao trabalho indocumentado na Região Metropolitana de São Paulo.
Maria Cristina Cacciamali
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Cadernos Prolam/USP, 2011 O presente trabalho investiga a compatibilidade do maior programa de crédito para exportação do governo brasileiro, o BNDES-EXIM, e de programas similares da Argentina e do Chile, com as regras da OMC sobre subsídios.
José Guilherme Moreno Caiado
doaj +1 more source