Results 111 to 120 of about 317,652 (262)

Factores de riesgo y medidas de control en brotes de sarampión en países de la Región de las Américas, 2017-2023

open access: yesRevista Panamericana de Salud Pública
Objetivo. Documentar y comparar los factores de riesgo y medidas de control de los brotes de sarampión de mayor magnitud en la era poseliminación en la Región de las Américas. Método.
Desirée Pastor   +5 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Lições da América: o problema do americanismo em Tocqueville Lessons from America: the problem of americanism in Tocqueville

open access: yesLua Nova: Revista de Cultura e Política, 1993
Quem deve prestar lições a quem: a América à Europa ou vice-versa? O autor interpreta o pensamento de Tocqueville à luz dessa questão, trabalhando com o conceito de americanismo - isto é, a conciliação que se tornou possível nos Estados Unidos, sem que rupturas revolucionárias ocorressem, entre estado social de igualdade e liberdade, entre ...
openaire   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Avaliação de clones de mandioca de mesa sob irrigação e em condições de sequeiro. [PDF]

open access: yes, 2012
A mandioca (Manihot esculenta Crantz) é uma planta originária das Américas, provavelmente do Brasil, e cultivada em todo o território brasileiro, com suas raízes e folhas largamente utilizadas na nossa culinária.
COELHO FILHO, M. A.   +4 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

DECLARACIÓN DE COMPROMISO DE PUERTO ESPAÑA QUINTA CUMBRE DE LAS AMÉRICAS PUERTO ESPAÑA, TRINIDAD Y TOBAGO

open access: yesAportes para la Integración Latinoamericana, 2017
Nosotras y Nosotros, las Jefas y los Jefes de Estado y de Gobierno de los países democráticos de las Américas, guiados por un espíritu renovado de cooperación, integración y solidaridad, nos hemos reunido en Puerto España en la Quinta Cumbre de las ...
Cumbre de Las Américas
doaj  

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