Results 111 to 120 of about 134,596 (256)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Universidad Especializada de las Américas

, 2009
81 p.
Torrijos de Arosemena, Berta
core   +1 more source

MMS Américas: a regional network for malaria molecular surveillance

Malaria Journal
International researchers and public health professionals convened in Panama in August 2025 to discuss current and future malaria molecular surveillance strategies to accelerate elimination in the Americas.
The MMS Américas Network
doaj   +1 more source

Estatuto Orgánico

, 2020
Que mediante Acuerdo del Consejo Técnico de Administración No. 001-2008 de 12 de junio de 2008, se aprobó el actual Estatuto Orgánico de la Universidad Especializada de las Américas (UDELAS); instrumento que después de 13 años requiere ser actualizado ...
Universidad Especializada de las Américas
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Regionalismo, derechos humanos y democratización en América: La importancia del contexto

Araucaria, 2008
El presente artículo plantea cuatro cuestiones relativas a los derechos humanos en las Américas: examina la especificidad de Latinoamérica como región a escala mundial; la teoría de las relaciones entre democratización y derechos humanos; la dimensión ...
Laurence Whitehead
doaj  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Propuesta interiorista de cambio de uso de área comercial a sede de clubes de la Universidad de las Américas

, 2015
The project sets out to accomplish an interior proposal for the clubs in the “Universidad de las Américas” which are necessary elements in the students educational training.
Bracho Ponce, María Emilia
core