Results 121 to 130 of about 3,579,030 (363)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Epidemiology of Chikungunya in the Americas
Journal of Infectious Diseases, 2016 Chikungunya virus (CHIKV) emerged in the Americas in late 2013 to cause substantial acute and chronic morbidity. About 1.1 million cases of chikungunya were reported within a year, including severe cases and deaths.
S. Yactayo +4 more
semanticscholar +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Cultura y administración de Recursos Humanos en América Latina.
Revista Galega de Economía, 2014 Las relaciones sociales y el respeto por la autoridad son caracterÃsticas del modelo de administración latinoa-mericana. Estas caracterÃsticas están basadas en valores del trabajo que forman un marco cultural apropiado para entender cómo las organizaciones latinoamericanas administran sus recursos humanos.
openaire +1 more source
Una alianza por la salud de los pueblos de las Américas : logros de los países con apoyo de la Cooperación Española y la Organización Panamericana de la Salud 2007-2013 [PDF]
, 2014 Los apartados destacados en esta publicación son solo una parte del trabajo realizado con el Fondo Español.En los últimos 20 años la Región de las Américas ha logrado un avance sostenido en la mejora de la salud de las personas, el acceso a los servicios
Agencia Española de Cooperación Internacional para el Desarrollo +2 more
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Precariedades y emergencias de Norte a Sur: reinvención, colaboración, expansión [PDF]
, 2014 En este breve artículo de opinión me detengo en las dinámicas de precarización laboral y en las formas de organización emergentes a lo largo de las Américas para dar cuenta de una nueva geografía del trabajo académico.
Depetris Chauvin, Irene
core
Patterns of antenal sensilla of Panstrongylus megistus from three Brazilian states [PDF]
, 2005 The objective of the present study was to analyze and describe the phenotype of the antennal sensilla of Panstrongylus megistus, one of the epidemiologically most important species of triatomines in Brazil.
Catala, Silvia Susana +4 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source