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3D Scanning of Porto Alegre Museum Artifacts: The Crockery of the Rocco Bakery [PDF]

Muzeológia a Kultúrne Dedičstvo, 2022
Antiques usually require careful handling, so these objects cannot be made available to the general public and are handled only by restoration specialists.
Andresa Richetti , Fabio Pinto da Silva, Liane Roldo +2 more
doaj +1 more source

Machine learning methods for developments of binding kinetic models in predicting protein‐ligand dissociation rate constants

Smart Molecules, Volume 1, Issue 3, December 2023., 2023
This paper develops a variety of binding kinetic models for predicting dissociation rate constants using eight machine learning methods, which are tested by two case studies involving the HSP90 and RIP1 kinase inhibitors. Both regression results of the two case studies indicate that the Bayesian neural network model has the state‐of‐the‐art prediction ...
Yujing Zhao +4 more
wiley +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +165 more
wiley +1 more source

Flood vulnerability and risk assessment of historic urban areas: Vulnerability evaluation, derivation of depth‐damage curves and cost–benefit analysis of flood adaptation measures applied to the historic city centre of Tomar, Portugal

Journal of Flood Risk Management, Volume 16, Issue 3, September 2023., 2023
Abstract Around 45% of natural hazards reported worldwide are related to floods, and current indications show that exposure to floods and inherent losses will keep escalating. Historic centres are particularly vulnerable in this context due to the structural and material characteristics of the buildings and because they embrace social and cultural ...
Lucy Davis +6 more
wiley +1 more source

Imaging of KCa3.1 Channels in Tumor Cells with PET and Small‐Molecule Fluorescent Probes

ChemMedChem, Volume 18, Issue 2, January 17, 2023., 2023
Highly aggressive human tumors use the Ca2+ activated K+ channel KCa3.1. for key processes of the metastatic cascade. Imaging of the KCa3.1 channel in vitro and in vivo represents a valuable diagnostic and prognostic tool. A 18‐fluorine labeled senicapoc‐based PET tracer showed promising imaging properties in vivo.
Insa Thale +9 more
wiley +1 more source

Supporting early infant relationships and reducing maternal distress with the Newborn Behavioral Observations: A randomized controlled effectiveness trial

Infant Mental Health Journal: Infancy and Early Childhood, Volume 43, Issue 3, Page 455-473, May 2022., 2022
Abstract Research points to the significant impact of maternal distress on the parent‐infant relationship and infant development. The Newborn Behavioral Observations (NBO) is a brief intervention supporting the infant, the parent and their relationship.
Susan Nicolson, Sarah‐Pia Carron, Campbell Paul +2 more
wiley +1 more source

3,5‐Dinitrobenzoate and 3,5‐Dinitrobenzamide Derivatives: Mechanistic, Antifungal, and In Silico Studies

Journal of Chemistry, Volume 2022, Issue 1, 2022., 2022
Fungal infections, including those caused by Candida spp., are recognized in immunocompromised individuals for their high rates of morbidity and mortality. Microorganism resistance to conventional drugs compromises treatment effectiveness and yet also reveals the need to develop new drugs.
Allana B. S. Duarte +5 more
wiley +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source

Proximity across the distant worlds of university–industry collaborations

Papers in Regional Science, Volume 100, Issue 3, Page 689-711, June 2021., 2021
Abstract This paper examines the extent to which firms perceive different dimensions of proximity to be important for the formation of their interactions with universities. Furthermore, it investigates whether the importance of the different types of proximities varies depending on the type of interaction—be it about knowledge exploration, knowledge ...
Utku Ali Rıza Alpaydın, Rune Dahl Fitjar +1 more
wiley +1 more source

Cytotoxic and Antifungal Amides Derived from Ferulic Acid: Molecular Docking and Mechanism of Action

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Amides derived from ferulic acid have a wide spectrum of pharmacological activities, including antitumor and antifungal activity. In the present study, a series of ten amides were obtained by coupling reactions using the reagents (benzotriazol‐1‐yloxy) tripyrrolidinophosphonium hexafluorophosphate (PyBOP) and N,N ′ -dicyclohexylcarbodiimide (DCC).
Mayara Castro de Morais +8 more
wiley +1 more source

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