Results 31 to 40 of about 93,002 (252)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Understanding the effect of MXene in a TMO/MXene hybrid catalyst for the oxygen evolution reaction

npj 2D Materials and Applications, 2023
Very recently, it has been reported that mixed transition metal oxide (TMO)/MXene catalysts show improved performance over TMO only catalysts for the oxygen evolution reaction (OER). However, the reasoning behind this observation is unknown. In this work
Daire Tyndall, Lee Gannon, Lucia Hughes, Julian Carolan, Sergio Pinilla, Sonia Jaśkaniec, Dahnan Spurling, Oskar Ronan, Cormac McGuinness, Niall McEvoy, Valeria Nicolosi, Michelle Philippa Browne   +11 more
doaj   +1 more source

Protective Effect of Amber Extract on Human Dopaminergic Cells against 6-Hydroxydopamine-Induced Neurotoxicity

Molecules, 2022
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disease, after Alzheimer’s disease. In our previous study, we found that amber—a fossilized plant resin—can protect cells from apoptosis by decreasing the generation of ...
Yuening Luo, Siqi Zhou, Reiko Takeda, Kazuma Okazaki, Marie Sekita, Kazuichi Sakamoto   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Video frame interpolation neural network for 3D tomography across different length scales

Nature Communications
Three-dimensional (3D) tomography is a powerful investigative tool for many scientific domains, going from materials science, to engineering, to medicine.
Laura Gambini, Cian Gabbett, Luke Doolan, Lewys Jones, Jonathan N. Coleman, Paddy Gilligan, Stefano Sanvito   +6 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Quantitative analysis of printed nanostructured networks using high-resolution 3D FIB-SEM nanotomography

Nature Communications
Networks of solution-processed nanomaterials are becoming increasingly important across applications in electronics, sensing and energy storage/generation.
Cian Gabbett, Luke Doolan, Kevin Synnatschke, Laura Gambini, Emmet Coleman, Adam G. Kelly, Shixin Liu, Eoin Caffrey, Jose Munuera, Catriona Murphy, Stefano Sanvito, Lewys Jones, Jonathan N. Coleman   +12 more
doaj   +1 more source

Broad Epitope Coverage of Therapeutic Multi-Antibody Combinations Targeting SARS-CoV-2 Boosts In Vivo Protection and Neutralization Potency to Corner an Immune-Evading Virus

Biomedicines
Therapeutic antibodies (Abs) which act on a broader range of epitopes may provide more durable protection against the genetic drift of a target, typical of viruses or tumors.
Ilse Roodink, Maartje van Erp, Andra Li, Sheila Potter, Sander M. J. van Duijnhoven, Milou Smits, Arthur J. Kuipers, Bert Kazemier, Bob Berkeveld, Ellen van Geffen, Britte S. de Vries, Danielle Rijbroek, Bianca Boers, Sanne Meurs, Wieger Hemrika, Alexandra Thom, Barry N. Duplantis, Roland A. Romijn, Jeremy S. Houser, Jennifer L. Bath, Yasmina N. Abdiche   +20 more
doaj   +1 more source

Analyzing vibration effect on amber buoying up velocity [PDF]

E3S Web of Conferences, 2019
Industrial use of hydromechanical method and equipment made it possible to represent quantitative assessment of parameters for efficient amber extraction from amber-bearing deposits. Mined-out deposits with non-commercial reserves, being technogenic ones,
Malanchuk Zynovii, Korniienko Valerii, Malanchuk Yevhenii, Moshynskyi Viktor   +3 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source