Results 41 to 50 of about 153,619 (302)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nature CommunicationsNetworks of solution-processed nanomaterials are becoming increasingly important across applications in electronics, sensing and energy storage/generation.
Cian Gabbett +12 more
doaj +1 more source
Understanding the effect of MXene in a TMO/MXene hybrid catalyst for the oxygen evolution reaction
npj 2D Materials and Applications, 2023 Very recently, it has been reported that mixed transition metal oxide (TMO)/MXene catalysts show improved performance over TMO only catalysts for the oxygen evolution reaction (OER). However, the reasoning behind this observation is unknown. In this work
Daire Tyndall +11 more
doaj +1 more source
Nanomaterials, 2023 This study is the second part of a two-part study whereby supersaturated solutions of calcium and phosphate ions generate well-defined hydroxyapatite coatings for orthopaedic implants. An ‘ideal’ process solution is selected from Part 1, and the detailed
Bríd Murphy +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
The first fossil cyphophthalmid harvestman from Baltic amber [PDF]
, 2011 The first fossil cyphophthalmid harvestman (Opiliones: Cyphophthalmi) from Palaeogene (Eocene) Baltic amber is described. This is only the third fossil example of this basal harvestman lineage; the others being from the probably slightly younger ...
Plamen G. Mitov +4 more
core +1 more source