Results 61 to 70 of about 153,619 (302)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

PREVENTION OF DEPRESSION IN CHILDREN - A LITERATURE REVIEW [PDF]

open access: yes, 2023
Amber Masood & Jennipher Nakato Prevention of depression in children - a literature review 38 Pages and 24 Attachments Spring 2023 Diaconia University of Applied Sciences Bachelor's degree in health care nursing Depression is one of the most ...
Masood, Amber, Nakato, Jennipher
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

More records of mosses from Dominican amber

open access: yes, 2006
Hypnum spec., Orthostichella cf. pentasticha, Syrrhopodon flexifolius and Porotrichum aff. substriatum are recorded from Dominican amber (c. 25 mio yrs. b.p.).
Frahm, Jan-Peter
core  

A botanical view of the ‘Baltic amber forest’: new evidence from seed plants, lichens and fungi [PDF]

open access: yes, 2019
Baltic amber forms the largest amber deposit on earth and it is particularly well-known for the plethora of arthropod inclusions. The floristic composition, habitat types and climate of its Eocene source area, however, are still controversial.
Kaasalainen, Ulla   +3 more
core  

Open Research Video Case Study (2023): Amber Copeland

open access: yes, 2023
Video case study detailing the open research practices for which Dr Copeland was awarded runner up prize in the University of Sheffield Open Research Prize 2023.This prize was awarded for integrating a number of open research practices, including pre ...
Amber Copeland (13892865)
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Amber in the Poem "De Rana et Lacerta, Succino Prussiaco Insitis" (About a Frog and a Lizard Embedded in Prussian Amber) by Daniel Hermann (1543—1601), a Humanist from Riga

open access: yes, 2016
Poet Daniel Hermann (1543–1601), a 16th-century humanist and diplomat from Prussia, authored the poem "About a Frog and a Lizard Embedded in Prussian Amber," which was published in Riga in 1600.
Kreigere-Liepiņa, Laura
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

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