Results 71 to 80 of about 429,402 (391)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Broad Epitope Coverage of Therapeutic Multi-Antibody Combinations Targeting SARS-CoV-2 Boosts In Vivo Protection and Neutralization Potency to Corner an Immune-Evading Virus

Biomedicines
Therapeutic antibodies (Abs) which act on a broader range of epitopes may provide more durable protection against the genetic drift of a target, typical of viruses or tumors.
Ilse Roodink, Maartje van Erp, Andra Li, Sheila Potter, Sander M. J. van Duijnhoven, Milou Smits, Arthur J. Kuipers, Bert Kazemier, Bob Berkeveld, Ellen van Geffen, Britte S. de Vries, Danielle Rijbroek, Bianca Boers, Sanne Meurs, Wieger Hemrika, Alexandra Thom, Barry N. Duplantis, Roland A. Romijn, Jeremy S. Houser, Jennifer L. Bath, Yasmina N. Abdiche   +20 more
doaj   +1 more source

First astrophysical results from AMBER/VLTI

, 2006
The AMBER instrument installed at the Very Large Telescope (VLT) combines three beams from as many telescopes to produce spectrally dispersed fringes from milli-arcsecond angular scale in the near infrared.
Collaboration, the AMBER consortium, De Souza, Armando Domiciano, Malbet, Fabien, Millour, Florentin, Petrov, Romain G., Stee, Philippe, Tatulli, Eric, Weigelt, Gerd   +7 more
core   +4 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Video frame interpolation neural network for 3D tomography across different length scales

Nature Communications
Three-dimensional (3D) tomography is a powerful investigative tool for many scientific domains, going from materials science, to engineering, to medicine.
Laura Gambini, Cian Gabbett, Luke Doolan, Lewys Jones, Jonathan N. Coleman, Paddy Gilligan, Stefano Sanvito   +6 more
doaj   +1 more source

Analyzing vibration effect on amber buoying up velocity [PDF]

E3S Web of Conferences, 2019
Industrial use of hydromechanical method and equipment made it possible to represent quantitative assessment of parameters for efficient amber extraction from amber-bearing deposits. Mined-out deposits with non-commercial reserves, being technogenic ones,
Malanchuk Zynovii, Korniienko Valerii, Malanchuk Yevhenii, Moshynskyi Viktor   +3 more
doaj   +1 more source

Coordinated AMBER and MIDI observations of the Mira variable RR Aql

, 2008
We have used near- and mid-infrared interferometry to investigate the pulsating atmosphere and the circumstellar environment of the Mira variable RR Aql.
David A. Boboltz, Eric Stempels, Iva Karovicova, Markus Wittkowski, Michael Scholz   +4 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Quantitative analysis of printed nanostructured networks using high-resolution 3D FIB-SEM nanotomography

Nature Communications
Networks of solution-processed nanomaterials are becoming increasingly important across applications in electronics, sensing and energy storage/generation.
Cian Gabbett, Luke Doolan, Kevin Synnatschke, Laura Gambini, Emmet Coleman, Adam G. Kelly, Shixin Liu, Eoin Caffrey, Jose Munuera, Catriona Murphy, Stefano Sanvito, Lewys Jones, Jonathan N. Coleman   +12 more
doaj   +1 more source

AMBER DROPLETS IN THE SOUTHERN ALPS (NE ITALY): A LINK BETWEEN THEIR OCCURRENCES AND MAIN HUMID EPISODES IN THE TRIASSIC

Rivista Italiana di Paleontologia e Stratigrafia, 2022
The Anisian amber from the “Voltzia beds” of the Recoaro area, produced by Voltzia recubariensis, represents the most ancient Triassic amber known so far.
GIUSEPPA FORTE, EVELYN KUSTATSCHER, EUGENIO RAGAZZI, GUIDO ROGHI   +3 more
doaj   +1 more source