Results 71 to 80 of about 71,380 (342)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

RobôFrango: Proof of concept of a mobile biosensor robot for environmental monitoring in broiler houses

Results in Engineering
The use of mobile sensors represents an innovative strategy for monitoring environmental variables in broiler houses, enabling the identification of conditions that directly affect animal welfare.
Glauber da Rocha Balthazar, Robson Mateus Freitas Silveira, Thauane Cordeiro Soares, Iran José Oliveira da Silva   +3 more
doaj   +1 more source

Development of a New Analytical Model for the Study of the Urban and Architectural Sound Ambiance: The Topological Approach

Proceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUA, 2019
Research in the field of ambiences has clearly evolved in our era, the field of investigation lists all the typologies of space ranging from architectural to urban space.
Selma SARAOUI, Azeddine Belakehal, Abdelghani ATTAR, Amar BENNADJI   +3 more
doaj   +1 more source

PIANO: Proximity-based User Authentication on Voice-Powered Internet-of-Things Devices

, 2017
Voice is envisioned to be a popular way for humans to interact with Internet-of-Things (IoT) devices. We propose a proximity-based user authentication method (called PIANO) for access control on such voice-powered IoT devices.
Bao, Xuan, Cao, Xiaoyu, Gong, Neil Zhenqiang, Jin, Hongxia, Ozen, Altay, Shin, Richard, Song, Dawn, Wu, Yu   +7 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Shading success: Optimizing climatic conditions and performance of feedlot Nellore cattle in the semi-arid belt [PDF]

Revista Brasileira de Zootecnia
The objective of this study was to evaluate, through principal component analysis, the effect of different feedlot structures on climatic conditions, nutrient intake, and performance of Nellore bulls during the feeding period in the semi-arid region ...
Evileide Marques de Oliveira, Cinara da Cunha Siqueira Carvalho, Flávio Pinto Monção, Heberth Christian Ferreira, Vicente Ribeiro Rocha Júnior, Maria Dulcinéia da Costa, José Reinaldo Mendes Ruas, Hellem Cristiane Mendes Rocha   +7 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Uso de algoritmo de otimização na determinação de tipos de animal funcional Use of optimization algorithm for determining of animal functional types

Ciência Rural, 2012
O presente trabalho teve como objetivo avaliar o uso de algoritmo de otimização na determinação de tipos funcionais de animais da raça Braford para diferentes condições ambientais. Foram utilizados algoritmos específicos de otimização por meio do progama
Carlos Eduardo Nogueira Martins, Sérgio Augusto Ferreira de Quadros, José Pedro Pereira Trindade, Fernando Luiz Ferreira de Quadros   +3 more
doaj