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An Introduction to Ambient Ionization Mass Spectrometry
, 2014 Ambient ionization/sampling mass spectrometry (or “ambient mass spectrometry” for short) is a subdiscipline of mass spectrometry that enables direct, high-throughput, surface analysis of native samples. Two flagship ambient mass spectrometry techniques: direct analysis in real time (DART) and desorption electrospray ionization (DESI) have not only ...
Monge, Maria Eugenia +1 more
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Thermal desorption ambient ionization mass spectrometry for emergency toxicology
Mass Spectrometry Reviews, 2022Abstract In the emergency department, it is important to rapidly identify the toxic substances that have led to acute poisoning because different toxicants or toxins cause poisoning through different mechanisms, requiring disparate therapeutic strategies and precautions against contraindicating actions, and diverse directions of ...
Hung, Su +3 more
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Microplasma Discharge Ionization Source for Ambient Mass Spectrometry
Analytical Chemistry, 2009In this paper, we demonstrate the first use of a microplasma ionization source for ambient mass spectrometry. This device is a robust, easy-to-operate microhollow discharge that enables ambient direct analysis of gaseous, liquid, and solid-phase samples with minimum requirements in terms of operating power and high purity gas consumption.
Joshua M, Symonds +3 more
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Ambient Ionization Mass Spectrometry Measurement of Aminotransferase Activity
Journal of the American Society for Mass Spectrometry, 2017A change in enzyme activity has been used as a clinical biomarker for diagnosis and is useful in evaluating patient prognosis. Current laboratory measurements of enzyme activity involve multi-step derivatization of the reaction products followed by quantitative analysis of these derivatives.
Xin, Yan +4 more
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Scanning probe electrospray ionization for ambient mass spectrometry
Rapid Communications in Mass Spectrometry, 2012RATIONALE Ambient sampling and ionization techniques have been attracting attention in imaging mass spectrometry because they offer the advantage of rapid testing. We have developed a method which exploits the fluid motion of charged solvents for both local sampling and ionization with a single vibrating ...
Yoichi, Otsuka +5 more
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Pocket-Size “MasSpec Pointer” for Ambient Ionization Mass Spectrometry
Analytical Chemistry, 2021Current ambient ionization sources for mass spectrometry (MS) are typically connected to gas cylinders, high-voltage supply, injection pump, and other accessory equipment, which hinder the popularization of MS in the field of on-site detection. Here, we developed a wireless pocket-size "MasSpec Pointer" (weights 65 g) based on arc discharge powered by ...
Yuze Li +6 more
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Ambient Ionization Mass Spectrometry
2014Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject.
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Detection of explosives on skin using ambient ionization mass spectrometry
Chemical Communications, 2007Single nanogram amounts of the explosives TNT, RDX, HMX, PETN and their mixtures were detected and identified in a few seconds on the surface of human skin without any sample preparation by desorption electrospray ionization (DESI) using a spray solution of methanol-water doped with sodium chloride to form the chloride adducts with RDX, HMX, and PETN ...
Dina R, Justes +3 more
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Ambient molecular imaging by desorption electrospray ionization mass spectrometry
Nature Protocols, 2008Desorption electrospray ionization (DESI) allows the direct analysis of ordinary objects or pre-processed samples under ambient conditions. Among other applications, DESI is used to identify and record spatial distributions of lipids and drug molecules in biological tissue sections.
Justin M, Wiseman +3 more
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Recent developments in ambient ionization techniques for analytical mass spectrometry
The Analyst, 2008Ambient ionization techniques enable the interrogation of a variety of samples in their native state by mass spectrometry, and are rapidly advancing all fields where screening for the presence of various analytes in a broadband and/or high-throughput fashion is desirable.
Glenn A, Harris +2 more
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