Results 131 to 140 of about 3,958,494 (277)

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

The VCPIP1‐UBE3A Deubiquitination‐Ubiquitination Cascade Contributes to Castration‐Resistant Prostate Cancer Progression

Advanced Science, EarlyView.
VCIPIP1 emerges as a molecular link between protein stability and prostate cancer progression. By deubiquitinating and stabilizing UBE3A, VCIPIP1 promotes p53 degradation and progression to castration‐resistant prostate cancer. Elevated VCIPIP1 expression is associated with shorter castration‐resistant prostate cancer–free survival, highlighting the ...
Fei Lin, Wen‐Cai Zheng, Yi‐Qiu Wang, Bin Lin, Yun‐Zhi Lin, Dong‐Ning Chen, Xiao‐Dong Li, Xue‐Yi Xue, Yong Wei, Ning Xu   +9 more
wiley   +1 more source

Mass Spectrometry of Solid Samples in Open Air Using Combined Laser Ionization and Ambient Metastable Ionization

, 2012
Mass spectrometry of solid samples in open air was carried out using combined laser ionization and metastable ionization time-of-flight mass spectrometry (LI-MI-TOFMS) in ambient environment for qualitative and semiquantitative (relative analyte ...
Jiang, Lan, Xie, Zhi Qiang, He, Xiang Nan, Gao, Yang, Lu, Yongfeng, Hu, W., Guo, L. B.   +6 more
core   +1 more source

Intelligent Polymer Electrolytes for Next‐Generation Zinc‐Based Energy Storage Devices

Advanced Science, EarlyView.
Intelligent polymer electrolytes are organized into a three‐level hierarchy that advances zinc‐based energy storage from passive ion conduction toward active, adaptive, and intelligent operation. Molecular regulation of Zn+ coordination, water activity, desolvation, ion flux, and interfaces underpins adaptive self‐healing, anti‐freezing, adhesion, and ...
Sanath Kumar, Jhansirani Kesavan, Muhammad Asim, Atul Verma, Yen‐Pei Fu   +4 more
wiley   +1 more source

Characteristics of Low-Temperature Plasma Ionization for Ambient Mass Spectrometry Compared to Electrospray Ionization and Atmospheric Pressure Chemical Ionization

, 2016
Ambient desorption/ionization mass spectrometry (ADI-MS) is an attractive method for direct analysis with applications in homeland security, forensics, and human health.
Carsten Engelhard (1790587), Anastasia Albert (2011765)   +1 more
core   +1 more source

Bioorthogonal Click‐to‐Disassemble Phthalocyanine Nanoassemblies for Precise Chemo‐Photodynamic Therapy against Hypoxic Tumors

Advanced Science, EarlyView.
A bioorthogonal “click‐to‐disassemble” strategy enables precise activation of self‐assembled phthalocyanine nanoassemblies for chemo‐photodynamic therapy. EGFR‐targeted activator triggers IEDDA‐mediated disruption of the quenched assemblies, restoring fluorescence and ROS generation while releasing tirapazamine.
Jiaxin Shen, Evelyn Y. Xue, Caixia Yang, Peter Chi Keung Cheung, Dennis K. P. Ng   +4 more
wiley   +1 more source

Space‐Charge‐Driven Nonlinear Charge Transport in Silicon Reconfigurable Nonlinear‐Processing Units

Advanced Science, EarlyView.
Many approaches to AI hardware focus on accelerating linear operations, yet nonlinearity underpins computational expressivity. Reconfigurable nonlinear‐processing units (RNPUs) are promising computational primitives that provide nonlinear transformations directly in hardware.
Jonas Kareem, Lorenzo Cassola, Reinier J. C. Cool, Janiek I. van van Slooten, Ray J. E. Hueting, Peter A. Bobbert, Wilfred G. van der van der Wiel   +6 more
wiley   +1 more source

Determination of Sulfites in Dried Fruits by Paper Spray Ionization Tandem Mass Spectrometry

Molecules
Sulfite, a widely used food additive, is subject to regulated labeling. The extraction of sulfite as the stable hydroxymethylsulfonate (HMS) form and its quantitative analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been ...
Donghoon Lee, Heejin Ro, Seoyoung Hwang, Minkyu Lee, Hyebeen Kim, Jaeyoung Heo, Sangwon Cha   +6 more
doaj   +1 more source

Microscopy ambient ionization mass spectrometry of bat wings.

, 2015
Tissue samples from the wings of healthy bats and individuals with white-nose syndrome were subjected to microscopy ambient ionization mass spectrometry (A). Pseudogymnoascus destructans infection was confirmed by the presence of fluorescent lesions when
Winifred F. Frick (312941), Michael J. Meehan (703785), Gregory G. Turner (157781), David S. Blehert (131573), A. Marm Kilpatrick (72521), Lena Gerwick (224905), Samantha J. Mascuch (703782), Wilna J. Moree (703783), Cheng-Chih Hsu (703784), Pieter C. Dorrestein (224907), Tina L. Cheng (209466)   +10 more
core   +1 more source

Peptide and protein assays using customizable bio-affinity arrays combined with ambient ionization mass spectrometry. [PDF]

Chem Sci, 2021
Zhang X, Wang W, Zare RN, Min Q.
europepmc   +1 more source