Results 171 to 180 of about 3,715,069 (278)

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Ambient Ionization Mass Spectrometry for Point-of-Care Diagnostics and Other Clinical Measurements. [PDF]

Clin Chem, 2016
Ferreira CR, Yannell KE, Jarmusch AK, Pirro V, Ouyang Z, Cooks RG.   +5 more
europepmc   +1 more source

VOCs Adsorption and Exchange Properties in Bispidine‐Based Mn(II) 1D CPs Made of Orthogonally Oriented Linear Chains

Chemistry – A European Journal, EarlyView.
Combining the chiral bispidine ligand L1 with MnCl2 affords coordination polymers (CPs) with an unusual topology for this family of compounds, consisting of orthogonally packed ribbon‐like one‐dimensional (1D) chains. Their behavior was investigated through single‐crystal‐to‐single‐crystal exchange with aromatic volatile organic compounds (VOCs) and ...
Meriem Goudjil, Martina Lippi, Sara Camorali, Chiara Pelosi, Alessandro Sayed, Luca Bernazzani, Patrizia Rossi, Paola Paoli, Massimo Cametti   +8 more
wiley   +1 more source

Metabolic Markers and Statistical Prediction of Serous Ovarian Cancer Aggressiveness by Ambient Ionization Mass Spectrometry Imaging. [PDF]

Cancer Res, 2017
Sans M, Gharpure K, Tibshirani R, Zhang J, Liang L, Liu J, Young JH, Dood RL, Sood AK, Eberlin LS.   +9 more
europepmc   +1 more source

Mild C─F Activation of Azido(per)Fluoroalkanes

Chemistry – A European Journal, EarlyView.
Mild and selective activation of C(sp3)–F bonds in azido(per)fluoroalkanes using thiolates was developed, leading to novel functionalized azides. The reaction is initiated by nucleophilic attack of the sulfur atom to the terminal nitrogen of the azido group, followed by fluoride ion elimination.
Olena Shaitanova, María Martínez Mallo, Sergii Suikov, Blanka Klepetářová, Josef Filgas, Petr Slavíček, Lucie Bednárová, Petr Beier   +7 more
wiley   +1 more source

Metal‐Ion Regulated Light‐Free Z→E Isomerization of Azobenzene Glycomacrocycle

Chemistry – A European Journal, EarlyView.
Metal ion‐catalyzed Z→E isomerization of photoswitchable azobenzene glycomacrocycle: A new azobenzene‐based glycomacrocycle is capable of forming a 1:1 complex with divalent metal ions in both E‐ and Z‐isomers. The complexes undergo light‐free Z→E isomerization in a timescale spanning from seconds to weeks.
Yang Zhou, Jinbiao Jiao, Mathieu Lordez, Jean‐Yves Salpin, Juan Xie   +4 more
wiley   +1 more source

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, EarlyView.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source

Coordination Chemistry of Boron Subphthalocyanine With BINOL Derivatives: Unexpected Oxidation to Oxa[4]Helicene and Properties of the Resulting Axially Coordinated Complexes Containing Oxa[4]Helicene and/or BINOL Derivatives

Chemistry – A European Journal, EarlyView.
Treatment of BINOL with a boron subphthalocyanine derivative resulted in the formation of a complex coordinated to an oxa[4]helicene derivative, which is generated via a ring‐closure reaction of BINOL. In contrast, treatment of the monomethyl ether of 1,1′‐bi‐2‐naphthol (BINOL) afforded the expected axially coordinated complex.
Shafikul Islam, Kazuyuki Asahi, Hiroyuki Nishikawa, Daiki Tauchi, Masashi Hasegawa, Ken‐ichi Sugiura   +5 more
wiley   +1 more source

Bismuth Chalcogenide‐Based Photocatalysts for Nitrogen Reduction: Recent Progress and Prospects

Chemistry – A European Journal, EarlyView.
Bismuth chalcogenides emerge as promising visible‐light photocatalysts for sustainable ammonia synthesis, driven by tunable electronic structures and strong N2 activation. Recent advances reveal how defects, doping and heterojunction design synergistically enhance charge separation and reactivity. Key challenges and future directions highlight pathways
Mukesh K. Verma, Muhammad D. Bala, Phindile B. Khoza, Tshephiso R. Papo, Mzamo L. Shozi   +4 more
wiley   +1 more source

Ru Nanoparticle Supported by Mesoporous SiOx and Pillared Montmorillonite: Suppressing Catalyst Inhibition in Carbon Dioxide Hydrogenation

Chemistry – A European Journal, EarlyView.
Ru nanoparticles confined within mesoporous SiOx‐pillared montmorillonite exhibit exceptional performance for CO2 methanation. The catalyst maintains a high reaction rate even at elevated CO2 conversion while preserving high Ru mass–specific activity, overcoming typical inhibition by H2O and CO observed in conventional supported Ru catalysts.
Seunghwan Jung, Zimu Miao, Yasuhiro Sakamoto, Fuminao Kishimoto, Kazuhiro Takanabe   +4 more
wiley   +1 more source