Results 171 to 180 of about 369,732 (282)

Ambiguities faced by parents who received a genetic diagnosis for autistic offspring with intellectual disabilities. [PDF]

J Community Genet
Klitzman R, Bezborodko E, Chung WK, Appelbaum PS.   +3 more
europepmc   +1 more source

Soft‐Drug‐Inspired MnSTF Nano‐Adjuvant for Safe and Synergistic cGAS–STING Activation in Tumor Immunotherapy

Advanced Science, EarlyView.
This study introduces MnSTF, a soft‐drug‐inspired nanoadjuvant that overcomes the systemic toxicity of STING agonists. Through Mn2+ coordination with an ENPP1 inhibitor, it enables safe cGAS‐STING activation, remodels the tumor immune microenvironment, and synergizes with radiotherapy or vaccines to elicit robust antitumor immunity.
Guangfei Sun, Jiancheng Pan, Rui Li, Ruoxi Li, Ziyan Liu, Jinhui Wu, Tingsheng Lin, Yiqiao Hu, Ahu Yuan   +8 more
wiley   +1 more source

Distributionally robust free energy principle for decision-making. [PDF]

Nat Commun
Shafiei A, Jesawada H, Friston K, Russo G.   +3 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

bloodAGENT: a versatile tool for blood group typing and genomic variation analysis. [PDF]

Bioinform Adv
Wittig M, Steiert TA, Gassner C, Franke A.   +3 more
europepmc   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Challenges and advances of implementing affirmative action policies within graduate nursing programs. [PDF]

Front Public Health
de Oliveira Navarro da Conceição Y, da Silva BP, Deus FR, Santos DS, Saidel MGB.   +4 more
europepmc   +1 more source

Ambiguous Genitalia [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2011
John C, Achermann, Erica A, Eugster, Dorothy I, Shulman   +2 more
openaire   +2 more sources

Wave‐Partition‐Governed Dual‐Site Spallation in Single Crystals

Advanced Science, EarlyView.
Crystalline anisotropy shapes shock‐wave propagation and the resulting damage evolution in single crystals. Large‐scale molecular dynamics and damage modeling uncover a dual‐spallation mechanism driven by anisotropic elasticplastic wave separation, which mitigates damage accumulation.
Youlin Zhu, Sheng Qian, Lianfu Qiu, Jianian Hu, Guoqiang Luo, Qiang Shen, Qi Tong   +6 more
wiley   +1 more source

Editorial: Exploring female intuition: insights into gendered information processing. [PDF]

Front Sociol
Isenman L, Sinclair M.
europepmc   +1 more source