Results 151 to 160 of about 39,999 (253)

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor   +5 more
wiley   +1 more source

Mechanism of syncope: role of ambulatory blood pressure monitoring and cardiovascular autonomic function assessment. [PDF]

open access: yesEur Heart J
Groppelli A   +13 more
europepmc   +1 more source

Lifestyle Factors Associated With Reflux Symptoms Without Erosive Esophagitis in Japanese Individuals With and Without Obesity Undergoing Health Checkups: A Cross‐Sectional Study

open access: yesJournal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT Background Non‐erosive reflux disease (NERD) is the most prevalent gastroesophageal reflux disease phenotype. However, lifestyle factors associated with reflux symptoms in the absence of erosive esophagitis, a presentation often classified as NERD in epidemiological studies, remain underexplored in Japan.
Seiji Shiota   +10 more
wiley   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

open access: yesClinical Endocrinology, Volume 105, Issue 3, Page 271-284, September 2026.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu   +5 more
wiley   +1 more source

Real‐World Evidence of the Effectiveness and Safety of Biosynthetic Semaglutide in Type 2 Diabetes: A Multicentre Study From Pakistan

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8438-8451, September 2026.
ABSTRACT Aims To evaluate the real‐world effectiveness, safety and patient‐reported outcomes of biosynthetic semaglutide in adults with type 2 diabetes mellitus (T2DM) receiving routine outpatient care in a cost‐constrained setting. Methods This 30‐week, prospective, multicentre, non‐interventional study enrolled adults with T2DM initiating ...
Arshad Hussain   +9 more
wiley   +1 more source

Critical Review of the Methodological Shortcoming of Ambulatory Blood Pressure Monitoring and Cognitive Function Studies. [PDF]

open access: yesClocks Sleep
Haghayegh S   +12 more
europepmc   +1 more source

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