Results 51 to 60 of about 113,129 (210)

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 4003-4016, November 2026.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Multi-centre randomised controlled trial of a smart phone-based event recorder alongside standard care versus standard care for patients presenting to the Emergency Department with palpitations and pre-syncope - the IPED (Investigation of Palpitations in the ED) study: study protocol for a randomised controlled trial

Trials, 2018
Background Palpitations and pre-syncope are together responsible for 300,000 annual Emergency Department (ED) attendances in the United Kingdom (UK). Diagnosis of the underlying rhythm is difficult as many patients are fully recovered on ED arrival; and ...
Matthew J. Reed, Neil R. Grubb, Christopher C. Lang, Rachel O’Brien, Kirsty Simpson, Mia Padarenga, Alison Grant, Sharon Tuck   +7 more
doaj   +1 more source

Wearable Morphology‐Adaptive in‐Ear Device With Active Cleansing Capability for Multimodal Health Monitoring

Advanced Materials, Volume 38, Issue 58, 16 October 2026.
We present SCIENCE, an in‐ear multimodal physiological monitor featuring two key innovations. Water‐triggered morphological expansion (a 2‐mm cylinder to a 9‐mm spindle) achieves conformal adaptation across complex canal geometries. Simultaneously, active biofouling mitigation disrupts cerumen barriers, reducing sensor‐skin impedance by 20%.
Shuyun Zhuo, Zihuan Wu, Anan Zhang, Shideh Kabiri Ameri   +3 more
wiley   +1 more source

Brain natriuretic peptide and high-sensitivity Troponin at 3 hours post emergency department attendance with unexplained syncope predict 90 day outcome

Emergency Care Journal, 2018
To investigate if Brain Natriuretic Peptide (BNP) and highsensitivity troponin I predict significant arrhythmia, symptomatic significant arrhythmia and 90-day death and/or Major Adverse Cardiac Event in Emergency Department (ED) unexplained syncope ...
Matthew James Reed, Hannah Brutin, Neil R. Grubb, Christopher C. Lang, Alasdair J. Gray, Kirsty Simpson, Allan MacRaild, Christopher J. Weir   +7 more
doaj   +1 more source

A Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment

Advanced Science, Volume 13, Issue 56, 9 October 2026.
ABSTRACT Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.
Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma   +27 more
wiley   +1 more source

Ambulatory-focused treatment modalities considered in the modelling studies for Belarus, the Republic of Moldova, and Romania.

, 2023
Ambulatory-focused treatment modalities considered in the modelling studies for Belarus, the Republic of Moldova, and Romania.
Hassan Haghparast-Bidgoli (3141792), Sarah J. Jarvis (16412731), Romesh Abeysuriya (8824172), Tom Palmer (159714), Rowan Martin-Hughes (4431142), David J. Kedziora (10573094), Nejma Cheikh (4487677), Stela Bivol (12119860), Gerard Joseph Abou Jaoude (13183848), Lara Goscé (11485929), David P. Wilson (9160266), Zara Shubber (279389), Nicole Fraser-Hurt (2636833), Jolene Skordis (6417764), Anna Roberts (8969096), Clemens Benedikt (230638), Sherrie L. Kelly (3753985)   +16 more
core   +1 more source

The utility of 24-h electrocardiogram recordings for the prediction of a sufficient number of premature ventricular complexes and mapping strategy during catheter ablation

Frontiers in Cardiovascular Medicine
Background and aimsAn insufficient number of premature ventricular complexes (PVCs) during catheter ablation (CA) may prohibit adequate mapping of the site of origin. Parameters to predict this situation have not been established.
Stine Aagaard-Nilsen, Stine Aagaard-Nilsen, Stine Aagaard-Nilsen, Lars Andreas Dejgaard, Lars Andreas Dejgaard, Ole-Gunnar Anfinsen, Erik Lyseggen, Torbjørn Holm, Trine S. Fink, Hans Henrik Odland, Knut Sevre, Erik Kongsgård, Finn Hegbom, Mathis Korseberg Stokke, Mathis Korseberg Stokke, Mathis Korseberg Stokke   +15 more
doaj   +1 more source

Expert Consensus on the Standardized Diagnosis, Treatment, and Management of Cancer in High‐Altitude Regions of China

Cancer Innovation, Volume 5, Issue 5, October 2026.
This expert consensus establishes standardized diagnostic, therapeutic, and management frameworks for cancers in high‐altitude regions of China, addressing epidemiological characteristics, tailored treatments, and highland‐specific adverse events to optimize care for plateau populations.
Yiqun Li, Feng Li, Xiaorong Bai, Yan Li, Chengyun Bai, Qiaomei Chang, Cuiping Guo, Ji Di, Qiuxia Dong, Mengting Da, Zhongcheng Li, Zhen Liu, Hongxia Liang, Yushuang Luo, Dengfeng Ren, Pengjie Yu, Rui Ma, Miaozhou Wang, Xueshan Zhao, Fuxing Zhao, Guoshuang Shen, Zhiping Feng, Hao Wang, Shengtao Zhou, Wenqiang Wei, Shanshan Chen, Lin Wang, Feng Du, Tseyang, Haifeng Xu, Xiaoling Ling, Gang Xu, Wei Guo, Yulan Zhao, Die Sang, Huachao Feng, Deqingwangmu, Gesangdeji, Basangdunzhu, Bianbazhaxi, Yixin Guo, Xinlong Tao, Guohui Bai, Wanpeng Yang, Hanhuan Luo, Yanming Lei, Cidanwangjiu, Fei Ma, Dong Wu, Jiuda Zhao   +49 more
wiley   +1 more source

Screening Strategies for Silent Myocardial Ischemia in Individuals With Diabetes Without Known Coronary Artery Disease: Systematic Review and Meta‐Analysis

Clinical Cardiology, Volume 49, Issue 10, October 2026.
Routine screening for silent myocardial ischemia in asymptomatic adults with diabetes detected occult coronary disease but did not reduce major cardiovascular events or mortality. Current evidence supports intensive cardiovascular risk‐factor management and selective cardiac testing when results are expected to change clinical management.
Vanessa del Carmen Romero Martínez, Juan Pablo Tobón Cuenca, Paula Alejandra Longas García, Luis Eduardo Salazar Moreno, Gloria Ibis Tirado Romero   +4 more
wiley   +1 more source

Sex-Specific Heart Rate Variability Associations With Vitamin B12, Folate, and Iron Status

Reviews in Cardiovascular Medicine
Background: The sex-specific impact of micronutrient status on heart rate variability (HRV) in adults presenting with palpitations to cardiology outpatient clinics remains unclear.
Mehmet ÖZYAŞAR, Selçuk ÖZTÜRK, Tolga MEMİOĞLU, Mehmet İNANIR   +3 more
doaj   +1 more source