Results 11 to 20 of about 518 (140)

Amebic Liver Abscess: An Unusual Cause of Budd-Chiari Syndrome. [PDF]

open access: yesCase Rep Infect Dis
Amebiasis is a significant public health issue in tropical regions, with liver abscess as its most common extraintestinal complication. Budd–Chiari syndrome secondary to amoebic liver abscess is rare and seldom reported. We present a 37‐year‐old man with poorly controlled Type 1 diabetes who developed fever, abdominal pain and distension.
Ajai Mokan Dasan SL, R R.
europepmc   +2 more sources

Recurrent amebic liver abscesses despite metronidazole treatment: A rare case report

open access: yesClinical Case Reports, Volume 11, Issue 11, November 2023., 2023
CT scan shows a percutaneous drain in the patient’s fourth liver abscess (blue arrow) and the occurrence of a new, fifth liver abscess (red arrow). Key Clinical Message Amebic liver abscesses should be considered in adult males with a liver abscess and a history of travel to endemic areas.
Sasan D. Noveir   +4 more
wiley   +1 more source

Discovery and Characterization of Multiple Classes of Human CatSper Blockers

open access: yesChemMedChem, Volume 17, Issue 15, August 3, 2022., 2022
High‐throughput screening identified seven hit series as novel inhibitors of the cation channel of sperm (CatSper), a validated male contraceptive target. CatSper channel blockade was confirmed by patch clamp electrophysiology. The most promising analog was found to be a potent CatSper inhibitor with high selectivity for CatSper over hCav1.2, hNav1.5 ...
Erick J. Carlson   +8 more
wiley   +1 more source

First report on the molecular detection of Entamoeba bovis from the endangered wild water buffalo (Bubalus arnee) in Nepal

open access: yesVeterinary Medicine and Science, Volume 8, Issue 2, Page 799-807, March 2022., 2022
1. The Asiatic wild water buffalo is an endangered species that are present only two areas in Nepal. 2. Microscopic examination revealed 96% prevalence rate with four protozoan and five helminths’ parasites detected in wild water buffalo. 3. PCR and sequencing revealed the presence of highly prevalent species as Entamoeba bovis. 4.
Menuka Aryal   +11 more
wiley   +1 more source

Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

open access: yesMedicinal Research Reviews, Volume 41, Issue 4, Page 2489-2564, July 2021., 2021
Abstract Endometriosis (EM) is defined as endometrial tissues found outside the uterus. Growth and development of endometriotic cells in ectopic sites can be promoted via multiple pathways, including MAPK/MEK/ERK, PI3K/Akt/mTOR, NF‐κB, Rho/ROCK, reactive oxidative stress, tumor necrosis factor, transforming growth factor‐β, Wnt/β‐catenin, vascular ...
Sze Wan Hung   +5 more
wiley   +1 more source

Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex

open access: yesCancer Science, Volume 110, Issue 12, Page 3788-3801, December 2019., 2019
Pimozide is identified as a migrastatic drug and ARPC2 inhibitor from connectivity map‐based drug discovery strategy. Pimozide inhibits migration and invasion in various cancer cell lines, and suppresses metastasis in an in vivo antimetastatic assay.
Jiyeon Choi   +8 more
wiley   +1 more source

Focus Issue on Male Infertility

open access: yesAdvances in Urology, Volume 2012, Issue 1, 2012., 2012
Male infertility problems can occur when sperms are limited in number or function. In this paper, we describe the clinical evaluation of male infertility. A detailed history, physical examination, and basic semen analysis are required. In addition, ultrasound, karyotyping, and hormonal studies are needed to determine specific causes of infertility.
Hideyuki Kobayashi   +3 more
wiley   +1 more source

The Aqueous Soluble Polyphenolic Fraction of Psidium guajava Leaves Exhibits Potent Anti‐Angiogenesis and Anti‐Migration Actions on DU145 Cells

open access: yesEvidence-Based Complementary and Alternative Medicine, Volume 2011, Issue 1, 2011., 2011
The aqueous extract of Psidium guajava budding leaves (PE) bears an extremely high content of polyphenolic and isoflavonoids. Whether it could be used as an anti‐tumor chemopreventive in view of anti‐angiogenesis and anti‐migration, we performed the assay methods including the MTT assay to examine the cell viability; the ELISA assay to test the ...
Chiung-Chi Peng   +4 more
wiley   +1 more source

The Role of Lipopeptidophosphoglycan in the Immune Response to Entamoeba histolytica

open access: yesBioMed Research International, Volume 2010, Issue 1, 2010., 2010
The sensing of Pathogen Associated Molecular Patterns (PAMPs) by innate immune receptors, such as Toll‐like receptors (TLRs), is the first step in the inflammatory response to pathogens. Entamoeba histolytica, the etiological agent of amebiasis, has a surface molecule with the characteristics of a PAMP.
Isabel Wong-Baeza   +8 more
wiley   +1 more source

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