CD40LG as a Biomarker in Rheumatoid Arthritis: Links to Bone Destruction and Interstitial Lung Disease ‐ A Bioinformatic Analysis With Clinical Validation [PDF]
Health Science ReportsBackground and Aims Biomarkers are essential tools in the diagnosis and management of various diseases. Rheumatoid arthritis (RA) is a systemic inflammatory disorder that frequently results in damage to joints and organs.
Chuanhui Yao +10 more
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Molecules, 2015 Ipecac alkaloids are secondary metabolites produced in the medicinal plant Psychotria ipecacuanha. Emetine is the main alkaloid of ipecac and one of the active compounds in syrup of Ipecac with emetic property. Here we evaluated emetine’s potential as an
Juliana Dias +2 more
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Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer [PDF]
Molecular OncologyAnaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK.
Sang‐Min Park +8 more
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Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells [PDF]
Cell Death DiscoveryAcute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effective control
Suellen L. R. Silva +12 more
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Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations [PDF]
Virus ResearchThe emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health.
Viktoriya S. Sidorenko +24 more
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CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach [PDF]
Frontiers in NeurologyPurposeGlioma remains a lethal malignancy with limited prognostic biomarkers. This study evaluates the prognostic significance and functional mechanisms of tetraspanin CD9 in glioma to establish its clinical relevance and identify therapeutic strategies ...
Yue Peng +7 more
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Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments
Life Science Alliance, 2022 This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis.
David Lukac +2 more
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Сибирский онкологический журнал, 2022 Objective: screening of previously selected DDIT4 inhibitors by their ability to suppress basal and glucocorticoid-induced expression of this gene in breast cancer (BC) cells, as well as evaluation of antiproliferative and cytotoxic effects of the ...
E. M. Zhidkova +9 more
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Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients. [PDF]
PLoS ONE, 2013 Although quantitative and qualitative granulocyte defects have been described in myelodysplastic syndromes (MDS), the underlying molecular basis of granulocyte dysfunction in MDS is largely unknown.
Xiaomin Feng +8 more
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Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus. [PDF]
PLoS Pathogens, 2016 Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we identified emetine
Rupkatha Mukhopadhyay +14 more
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