Results 1 to 10 of about 5,685 (85)

Emetine and Its Derivatives as Anticancer Agents Targeting the PI3K/AKT/mTOR Pathway: A Narrative Review of Mechanisms, Pharmacology, and Clinical Insights. [PDF]

J Cell Mol Med
ABSTRACT Emetine (EMT), a naturally occurring tetrahydroisoquinoline alkaloid, shows diverse biological actions, including anticancer effects. Despite existing studies, the role of EMT derivatives in cancer, particularly in relation to the PI3K/AKT/mTOR signalling pathway, remains largely underexplored.
Khatun MI, Selim S, Malik AH, Al Hasan MS, Khalipha ABR, Yana NT, Alshahrani MY, Hossain MA, Rakib IH, Chakrabarty A, Mia E.   +10 more
europepmc   +2 more sources

A RiboCancer cell line panel reveals that CLL-associated Rps15 mutations translationally rewire transcription through codon-specific tRNA accommodation defects. [PDF]

Hemasphere
Abstract Recurrent point mutations in ribosomal proteins (RPs) RPL10 and RPS15 are found in T‐cell acute lymphoblastic leukemia (T‐ALL) and chronic lymphocytic leukemia (CLL), respectively. Furthermore, deletions of RPL5, RPL11, and RPL22 are frequent in hematologic diseases such as Diamond Blackfan Anemia, T‐ALL, multiple myeloma, and in a variety of ...
Astier A, Caruso M, Vereecke S, Santo PE, Capron C, Froment C, Rinaldi D, Cabrerizo Granados D, Leclercq M, Royaert J, Verbeeck J, Pasau N, Plassart L, Pepe D, Verbruggen S, Paraqindes H, Lebaron S, Marcel V, Durand S, Chapat C, Menschaert G, Close P, Rapino F, Catez F, Marcoux J, Plisson-Chastang C, De Keersmaecker K.   +26 more
europepmc   +2 more sources

A Novel tRNA Half mt-5'-tiRNA-Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation. [PDF]

Adv Sci (Weinh)
A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Gu X, Zhu D, Liu X, Hu S, Yang X, Nie J, Xu T, Pan Y, Xu M, Sun H, Wang S.   +10 more
europepmc   +2 more sources

CD40LG as a Biomarker in Rheumatoid Arthritis: Links to Bone Destruction and Interstitial Lung Disease - A Bioinformatic Analysis With Clinical Validation. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Biomarkers are essential tools in the diagnosis and management of various diseases. Rheumatoid arthritis (RA) is a systemic inflammatory disorder that frequently results in damage to joints and organs. Here, we examined potential biomarkers and therapeutic agents for RA patients.
Yao C, Xu H, Gong X, Ma X, Yang Y, Dou D, Peng Q, Jiao J, Tang X, Jiang Q, Xia C.   +10 more
europepmc   +2 more sources

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

Closing the Translational Gap: Closed‐Loop AI Discovery Frameworks for Experimental Validation and Clinical Implementation in Cancer Therapeutics

Cancer Medicine, Volume 15, Issue 8, August 2026.
Artificial intelligence accelerates cancer therapeutic development through an iterative, closed‐loop pipeline: from AI‐driven target and drug discovery, through automated synthesis and screening, to experimental validation in in vivo tumor models, culminating in clinical translation guided by patient data.
Tuğba Ören Varol, Mehmet Varol
wiley   +1 more source

TALDO1 promotes lipid metabolic reprogramming and immunosuppressive microenvironment remodelling in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Deep autoencoder algorithm identified TALDO1 as a key metabolic gene associated with HCC progression. TALDO1 promotes lipid synthesis and accumulation in HCC cells and participates in lipid metabolic reprogramming. TALDO1 is associated with immunosuppressive microenvironment remodelling, and targeting TALDO1 reduces the infiltration of ...
Fenglin Lv, Huaxin Zhou, Jingyan Yang, Jianglei Xu, Fanqing Bi, Yi Zhou, Hao Zhang, Qian Ye, Lin Gao, Bin Jin   +9 more
wiley   +1 more source

Probing 5‐Nitroimidazole‐Triazole Hybrids as Potential Anti‐Kinetoplastid Agents: Synthesis and In Vitro Efficacy

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira, Gideon D. Badenhorst, Janine Aucamp, Keisuke Suganuma, David D. N’Da   +4 more
wiley   +1 more source

Synthesis, Electrochemistry, In Vitro Antiprotozoal Efficacy and Mechanistic Study of Novel ‘Ferrantoin’ and Related Derivatives

Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.
1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman, Janine Aucamp, Helena D. Janse van Rensburg, Christina Kannigadu, Rotondwa Mphephu, Andrew J. Swarts, Keisuke Suganuma, David D. N'Da   +7 more
wiley   +1 more source

C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution

ChemistrySelect, Volume 11, Issue 21, 4 June 2026.
The isoquinoline ring can be easily functionalized at C‐4 through a radical‐oxidative substitution process. The resulting products can be readily cyclized under basic conditions, facilitating the construction of pyranones fused to the isoquinoline scaffold. ABSTRACTIn this work, we report a straightforward synthetic procedure that enables the selective
Oscar Coral, Cesar A. Mujica‐Martinez, Alfredo Vázquez   +2 more
wiley   +1 more source