Results 11 to 20 of about 5,579 (176)

A RiboCancer cell line panel reveals that CLL-associated Rps15 mutations translationally rewire transcription through codon-specific tRNA accommodation defects. [PDF]

Hemasphere
Abstract Recurrent point mutations in ribosomal proteins (RPs) RPL10 and RPS15 are found in T‐cell acute lymphoblastic leukemia (T‐ALL) and chronic lymphocytic leukemia (CLL), respectively. Furthermore, deletions of RPL5, RPL11, and RPL22 are frequent in hematologic diseases such as Diamond Blackfan Anemia, T‐ALL, multiple myeloma, and in a variety of ...
Astier A, Caruso M, Vereecke S, Santo PE, Capron C, Froment C, Rinaldi D, Cabrerizo Granados D, Leclercq M, Royaert J, Verbeeck J, Pasau N, Plassart L, Pepe D, Verbruggen S, Paraqindes H, Lebaron S, Marcel V, Durand S, Chapat C, Menschaert G, Close P, Rapino F, Catez F, Marcoux J, Plisson-Chastang C, De Keersmaecker K.   +26 more
europepmc   +2 more sources

Poly (ADP-Ribose) Glycohydrolase-Dependent dePARylation of PCNA Is Essential for DNA Replication. [PDF]

FASEB J
The schematic illustration of PARG‐mediated dePARylation in DNA replication. In the normal physiological condition, PARG functions as an eraser to remove PAR from PCNA and promote the interaction between FEN1 and PCNA (A). Interruption of PARG results in the accumulation of PARs in DNA replication sites, represses the interaction between PCNA and FEN1,
Yan Z, Feng Q, Jiang X, Han X, Qiao Z, Wang Y, Yang X, Liu X, Cheng X, Guo S, Li H, Wu C.   +11 more
europepmc   +2 more sources

Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles

Cells, 2022
Chloroquine and Emetine are drugs used to treat human parasitic infections. In addition, it has been shown that these drugs have an antiviral effect.
Pavel Spirin, Elena Shyrokova, Valeria Vedernikova, Timofey Lebedev, Vladimir Prassolov   +4 more
doaj   +1 more source

Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses

Pharmaceuticals, 2020
The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat ...
Martin D. Bleasel, Gregory M. Peterson
doaj   +1 more source

THE PHARMACOLOGY OF EMETIN [PDF]

The American Journal of the Medical Sciences, 1916
n ...
Pellini, Emil J., Wallace, George B.
openaire   +1 more source

Emetine Is Not Ipecac: Considerations for Its Use as Treatment for SARS-CoV2

Pharmaceuticals, 2020
Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity.
Martin D. Bleasel, Gregory M. Peterson
doaj   +1 more source

Deep Transfer Learning Approach for Automatic Recognition of Drug Toxicity and Inhibition of SARS-CoV-2

Viruses, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19 and is responsible for the ongoing pandemic. Screening of potential antiviral drugs against SARS-CoV-2 depend on in vitro experiments, which are based on the quantification of ...
Julia Werner, Raphael M. Kronberg, Pawel Stachura, Philipp N. Ostermann, Lisa Müller, Heiner Schaal, Sanil Bhatia, Jakob N. Kather, Arndt Borkhardt, Aleksandra A. Pandyra, Karl S. Lang, Philipp A. Lang   +11 more
doaj   +1 more source

D1/D5 receptor activation promotes long-term potentiation and synaptic tagging/capture in hippocampal area CA2. [PDF]

FEBS J
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Chua K, Chong YS, Sajikumar S.
europepmc   +2 more sources

Puromycin reactivity does not accurately localize translation at the subcellular level

eLife, 2020
Puromycin is a tyrosyl-tRNA mimic that blocks translation by labeling and releasing elongating polypeptide chains from translating ribosomes. Puromycin has been used in molecular biology research for decades as a translation inhibitor. The development of
Syed Usman Enam, Boris Zinshteyn, Daniel H Goldman, Madeline Cassani, Nathan M Livingston, Geraldine Seydoux, Rachel Green   +6 more
doaj   +1 more source

Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences

Molecular Biomedicine, 2020
The global pandemic of COVID-19 has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Although currently several of clinically used “old” drugs have been repurposed to this new disease for the urgent clinical investigation ...
Aoli Wang, Yong Sun, Qingwang Liu, Hong Wu, Juan Liu, Jun He, Junling Yu, Qing Qing Chen, Yinglu Ge, Zhuhui Zhang, Chen Hu, Cheng Chen, Ziping Qi, Fengming Zou, Feiyang Liu, Jie Hu, Ming Zhao, Tao Huang, Beilei Wang, Li Wang, Wei Wang, Wenchao Wang, Tao Ren, Jing Liu, Yehuan Sun, Song Fan, Qibing Wu, Chaozhao Liang, Liangdan Sun, Bin Su, Wei Wei, Qingsong Liu   +31 more
doaj   +1 more source