Emetine is not ipecac: considerations for its use as treatment for SARS-CoV2 [PDF]
Pharmaceuticals, 2020 Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity. Historically, emetine was used to treat patients with Spanish influenza, in the last stages of the
Martin Bleasel (14731945) +1 more
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Emetine, ipecac, ipecac alkaloids and analogues as potential antiviral agents for coronaviruses
Pharmaceuticals, 2020 The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat ...
Martin Bleasel (14731945) +1 more
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Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus. [PDF]
PLoS Pathogens, 2016 Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we identified emetine
Xin Hu (38924) +29 more
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Emetine Di-HCl Attenuates Type 1 Diabetes Mellitus in Mice
Molecular Medicine, 2016 Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by β cell destruction, insulin deficiency and hyperglycemia. Activated macrophages and autoimmune T cells play a crucial role in the pathogenesis of hyperglycemia in NOD murine ...
Harold A Silverman +20 more
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Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine [PDF]
eLife, 2014 Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies.
Hanssen, E +8 more
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European Journal of Medicinal Chemistry ReportsThe outbreak of COVID-19 pandemic caused by the infection of SARS-CoV-2, has become a global crisis, threatening public health and disrupting global economy.
Subhajit Dinda +5 more
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Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments
Life Science Alliance, 2022 This study clarifies the long-standing misuse of emetine as a lagging strand synthesis-specific inhibitor. Emetine blocks the synthesis of both DNA strands by the inhibition of protein biosynthesis.
David Lukac +2 more
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Сибирский онкологический журнал, 2022 Objective: screening of previously selected DDIT4 inhibitors by their ability to suppress basal and glucocorticoid-induced expression of this gene in breast cancer (BC) cells, as well as evaluation of antiproliferative and cytotoxic effects of the ...
E. M. Zhidkova +9 more
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Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients. [PDF]
PLoS ONE, 2013 Although quantitative and qualitative granulocyte defects have been described in myelodysplastic syndromes (MDS), the underlying molecular basis of granulocyte dysfunction in MDS is largely unknown.
Xiaomin Feng +8 more
doaj +1 more source
Illustrations from the Wellcome Institute Library. Sir Henry Dale's laboratory notebooks, 1914-1919. [PDF]
, 1990 PMCID ...
Tansey, EM
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