Results 41 to 50 of about 6,696 (158)

The effect of emetine on myocardial catecholamine metabolism

, 1974
The effects of emetine on the uptake and release of noradrenaline from the isolated, perfused, rat heart and on the in vivo myocardial retention of noradrenaline have been studied.
R F Albrecht, E T Toyooka, D J Miletich, A D Ivankovic   +3 more
core   +1 more source

Emetine disrupts HCMV mediated MDM2-p53 complex.

, 2016
A) MDM2 and p53 expression increases with emetine treatment. Cells were seeded at 0.5 or 2 million cells/plate, infected with HCMV Towne followed by treatment with emetine (75 nM) or GCV (5 μM).
Xin Hu (38924), Xin Xu (11989), Rupkatha Mukhopadhyay (106864), Andrés E. Dulcey (2475010), Juan J. Marugan (191299), Ravit Arav-Boger (116842), Amy Q. Wang (1395658), Yu-Pin Su (2851958), Noel Southall (187625), Marc Ferrer (191300), Lesley Mathews Griner (2851961), Elena Barnaeva (1316694), Wenjuan Ye (2088499), Sujayita Roy (409389), Rajkumar Venkatadri (1314918)   +14 more
core   +1 more source

Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles. [PDF]

PLoS ONE, 2015
Small molecule based therapeutic intervention of amyloids has been limited by their low solubility and poor pharmacokinetic characteristics. We report here, the use of water soluble poly lactic-co-glycolic acid (PLGA)-encapsulated curcumin and emetine ...
Ankit Srivastava, Prabha Arya, Surbhi Goel, Bishwajit Kundu, Prashant Mishra, Ashish Fnu   +5 more
doaj   +1 more source

Targeting mucormycosis polyprotein (RVT_1 region) through antifungal phytochemicals: An in-silico perspective

Informatics in Medicine Unlocked, 2022
Mucormycosis has become a global issue due to its potential to infect and destroy organs, as well as its high fatality rate. Co-infecting with Covid 19 or when infecting after Covid 19, it becomes more lethal.
Anik Banik, Sheikh Rashel Ahmed, Hlamrasong Marma, Shiuly Sinha, Md. Mostafigur Rahman Khan, Kawsar Miah   +5 more
doaj   +1 more source

Synthesis of substituted allyl acetates from heterocyclic dienes by Pd-promoted arylation-acetoxylation cascade [PDF]

Journal of the Serbian Chemical Society, 2017
Pd-catalysed arylation–acetoxylation cascade, a previously reported methodology, was applied in the functionalisation of unsymmetrical dienes. Both explored classes of compounds, isoquinoline and β-carboline-derived dienes, afforded single regioisomers ...
Simić Milena R., Petković Miloš R., Jovanović Predrag M., Tasić Gordana D., Savić Vladimir M.   +4 more
doaj   +1 more source

Model of HCMV inhibition by emetine.

, 2016
In high-density infected cells (A) emetine induces (1) nuclear translocation of RPS14 (2) followed by RPS14 binding to MDM2 (3 & 4) resulting in disruption of the interaction between MDM2-p53 (6) and MDM2- viral IE2 (5 & 7), and by RPS14 ubiquitination ...
Xin Hu (38924), Xin Xu (11989), Rupkatha Mukhopadhyay (106864), Andrés E. Dulcey (2475010), Juan J. Marugan (191299), Ravit Arav-Boger (116842), Amy Q. Wang (1395658), Yu-Pin Su (2851958), Noel Southall (187625), Marc Ferrer (191300), Lesley Mathews Griner (2851961), Elena Barnaeva (1316694), Wenjuan Ye (2088499), Sujayita Roy (409389), Rajkumar Venkatadri (1314918)   +14 more
core   +1 more source

Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells

Cell Death Discovery
Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effective control
Suellen L. R. Silva, Ingrid R. S. B. Dias, Ana Carolina B. da C. Rodrigues, Rafaela G. A. Costa, Maiara de S. Oliveira, Gabriela A. da C. Barbosa, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Nainita Roy, Christopher Y. Park, Daniel P. Bezerra   +12 more
doaj   +1 more source

Unveiling FOS as a Potential Diagnostic Biomarker and Emetine as a Prospective Therapeutic Agent for Diabetic Nephropathy

Journal of Inflammation Research, 2023
Jiaqiong Lin,1 Xiaoyong Li,2 Yan Lin,3 Zena Huang,3 Fei He,4 Fu Xiong4,5 1Dongguan Maternal and Child Health Care Hospital, Postdoctoral Innovation Practice Base of Southern Medical University, Dongguan, People’s Republic of China; 2General Surgery ...
Lin J, Li X, Lin Y, Huang Z, He F, Xiong F   +5 more
doaj  

Electrochemical Investigation of the Redox Behavior of Isoquinoline Alkaloid Emetine [PDF]

ACS Omega
Smith C, Bonner J, Assimewlui E, Tucker K, Pereyra Cuello E, Sellers C, King T, Smith C, Friedman Z, Gebrehiwot W, Bakare O, Li Y, Udeochu U.   +12 more
europepmc   +2 more sources

Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei)

Molecules, 2008
The potential induction of a programmed cell death (PCD) in Trypanosoma b. brucei by 55 alkaloids of the quinoline, quinolizidine, isoquinoline, indole, terpene, tropane, steroid, and piperidine type was studied by measuring DNA fragmentation and changes
Michael Wink, Vera Rosenkranz
doaj   +1 more source