Results 41 to 50 of about 5,579 (176)
ChemMedChem, Volume 21, Issue 13, 14 July 2026.A series of 5‐nitroimidazole‐1,2,3‐triazole hybrids was synthesised and evaluated for antitrypanosomatid activity to assess their potential as treatments against leishmaniasis and trypanosomiasis. No notable in vitro activity against Leishmania was detected.
Liandi Ferreira +4 more
wiley +1 more source
Applied Organometallic Chemistry, Volume 40, Issue 7, July 2026.1,2‐Disubstituted ferrocene analogues bearing hydantoin or rhodanine synthons were synthesised and assessed for antitrypanosomatid activity. An antileishmanial early lead, analogue 23, acting through ROS generation and hence oxidative stress, was uncovered.
Maryna Saayman +7 more
wiley +1 more source
Journal of Inflammation Research, 2023 Jiaqiong Lin,1 Xiaoyong Li,2 Yan Lin,3 Zena Huang,3 Fei He,4 Fu Xiong4,5 1Dongguan Maternal and Child Health Care Hospital, Postdoctoral Innovation Practice Base of Southern Medical University, Dongguan, People’s Republic of China; 2General Surgery ...
Lin J +5 more
doaj
Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei)
Molecules, 2008 The potential induction of a programmed cell death (PCD) in Trypanosoma b. brucei by 55 alkaloids of the quinoline, quinolizidine, isoquinoline, indole, terpene, tropane, steroid, and piperidine type was studied by measuring DNA fragmentation and changes
Michael Wink, Vera Rosenkranz
doaj +1 more source
C4 Functionalization of the Isoquinoline Core via Oxidative Radical Substitution
ChemistrySelect, Volume 11, Issue 21, 4 June 2026.The isoquinoline ring can be easily functionalized at C‐4 through a radical‐oxidative substitution process. The resulting products can be readily cyclized under basic conditions, facilitating the construction of pyranones fused to the isoquinoline scaffold. ABSTRACTIn this work, we report a straightforward synthetic procedure that enables the selective
Oscar Coral +2 more
wiley +1 more source
Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine
Viruses, 2019 Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases.
Petter I. Andersen +14 more
doaj +1 more source
Food Risk Assess Europe, Volume 4, Issue 2, April 2026.Abstract Mycotoxins (mould toxins) are secondary metabolites of moulds. They are natural toxins whose occurrence in food and feed is undesirable but cannot be completely avoided. Mycotoxins may occur as contaminants in plant products and raw materials such as grains, nuts and almonds if they are infested with mould during cultivation, storage or ...
German Federal Institute for Risk Assessment (BfR)
wiley +1 more source
Investigating antimalarial drug interactions of emetine dihydrochloride hydrate using CalcuSyn-based interactivity calculations. [PDF]
PLoS ONE, 2017 The widespread introduction of artemisinin-based combination therapy has contributed to recent reductions in malaria mortality. Combination therapies have a range of advantages, including synergism, toxicity reduction, and delaying the onset of ...
Holly Matthews +4 more
doaj +1 more source
Transaminase and Norcoclaurine Synthase One‐Pot Cascades Towards (1S)‐Tetrahydroisoquinolines
ChemBioChem, Volume 27, Issue 6, 27 March 2026.A TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Jianxiong Zhao +5 more
wiley +1 more source