Results 51 to 60 of about 5,579 (176)

Therapeutic potential of natural alkaloid emetine against emerging COVID-19 and future viral pandemics

European Journal of Medicinal Chemistry Reports
The outbreak of COVID-19 pandemic caused by the infection of SARS-CoV-2, has become a global crisis, threatening public health and disrupting global economy.
Biswanath Dinda, Subhajit Dinda, Manikarna Dinda, Indrajit Sil Sarma, Santanu Majumdar, Shekhar Saha   +5 more
doaj   +1 more source

Comparison of anorectic potencies of the trichothecenes T-2 toxin, HT-2 toxin and satratoxin G to the ipecac alkaloid emetine

Toxicology Reports, 2015
Trichothecene mycotoxins, potent translational inhibitors that are associated with human food poisonings and damp-building illnesses, are of considerable concern to animal and human health.
Wenda Wu, Hui-Ren Zhou, Xiao Pan, James J. Pestka   +3 more
doaj   +1 more source

Isolation of 3β‐Hydroxylupenal From Ceriops decandra Leaves and Evaluation of In Vivo Analgesic and Anti‐Inflammatory Effects Supported by Molecular Docking

BioMed Research International, Volume 2026, Issue 1, 2026.
Ceriops decandra (Griff.) Ding Hou, locally known as “Goran” in Bangladesh, is a recognized mangrove plant of the Sundarbans. Coastal communities living in tidal areas traditionally use this plant for treating various ailments. While numerous biological activities of this plant have been reported, its leaves of Bangladeshi origin have not been ...
Asef Raj, Sania Ashrafi, Md. Sakhawat Hossain, Md. Saiful Islam, Muhammad Abdullah Al-Mansur, Abu Bin Ihsan, Md. Ruhul Kuddus, Firoj Ahmed, Baisakhi Banerjee   +8 more
wiley   +1 more source

Chirale Ökonomie

CHIMIA, 1976
A short introduction illustrates the concept of chiral economical syntheses and the advantages of the corresponding approaches. Using the total synthesis of emetine according to the work of Openshaw and Whittaker and the total synthesis of the steroid ...
A. Fischli
doaj   +1 more source

New drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing. [PDF]

PLoS ONE, 2018
Atypical meningiomas are common central nervous system neoplasms with high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical excision and radiotherapy remains the mainstay therapy but medical treatments are limited. We
Zsolt Zador, Andrew T King, Nophar Geifman   +2 more
doaj   +1 more source

The Hierarchical Contribution of Organic vs. Conventional Farming, Cultivar, and Terroir on Untargeted Metabolomics Phytochemical Profile and Functional Traits of Tomato Fruits

Frontiers in Plant Science, 2022
In this work, the impact of terroir, cultivar, seasonality, and farming systems on functional traits of tomato was hierarchically investigated. Untargeted metabolomics, antioxidant capacity, colorimetric assays, and enzyme inhibition were determined. The
Gabriele Rocchetti, Biancamaria Senizza, Gokhan Zengin, Paolo Bonini, Luana Bontempo, Federica Camin, Federica Camin, Marco Trevisan, Luigi Lucini   +8 more
doaj   +1 more source

Antibacterial Activity of Zanthoxylum chalybeum, Aloe deserti, and Zanthoxylum usambarense

BioMed Research International, Volume 2026, Issue 1, 2026.
Various Gram‐positive and Gram‐negative enteric pathogens are responsible for bacterial gastroenteritis, and this condition is commonly treated with antibiotics. But, the growing prevalence of antimicrobial resistance and drug‐associated toxicities has diminished the effectiveness of conventional drugs, prompting the need for alternative remedies ...
Stephen Mugambi Maithulia, Careen Ihazano Chumba, John Muthini Maingi, David Ng’ang’a Mburu, Eliud Nyaga Mwaniki Njagi, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

Inhibitors of RNA and protein synthesis cause Glut4 translocation and increase glucose uptake in adipocytes

Scientific Reports, 2022
Insulin stimulates glucose uptake in adipocytes by triggering translocation of glucose transporter 4-containg vesicles to the plasma membrane. Under basal conditions, these vesicles (IRVs for insulin-responsive vesicles) are retained inside the cell via ...
A. B. Meriin, N. Zaarur, J. S. Bogan, K. V. Kandror   +3 more
doaj   +1 more source

Plant Hormone Cytokinin as Aggregation Modulator of Gelsolin Amyloidosis

Journal of Peptide Science, Volume 31, Issue 10, October 2025.
Gelsolin peptides form amyloids, and aggregation is accelerated by a single point mutation. The gelsolin amyloids can be inhibited using plant hormones. ABSTRACT Amyloidosis, a self‐assembly of proteins or peptides, is associated with numerous degenerative diseases, such as gelsolin amyloidosis, which remain without a cure. Gelsolin protein is an actin‐
Dev Seneviratne, Naomi Stock, Tyra Lewis, R. J. Neil Emery, Sanela Martic   +4 more
wiley   +1 more source