Results 71 to 80 of about 6,696 (158)
Angustinine – A New Benzopyridoquinolizine Alkaloid from
Natural Product Communications, 2012 A new benzopyridoquinolizine alkaloid, designated as angustinine (1), was isolated from the root bark of Alangium lamarckii Thwaites, along with the known ipecac alkaloid, emetine.
Mumu Chakraborty, Sibabrata Mukhopadhyay
doaj +1 more source
Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, Volume 20, Issue 18, September 25, 2025.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
Frontiers in Pharmacology, 2020 The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public health.
Zhonglei Wang, Zhonglei Wang, Liyan Yang
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Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond
MedComm, Volume 6, Issue 9, September 2025.The potential of natural compounds to modulate the Hippo/YAP signaling pathway, a critical regulator of cell proliferation, differentiation, and survival, is explored. Dysregulation of this pathway is associated with various cancers, making it a target for therapeutic intervention.
Rajni Bala +13 more
wiley +1 more source
, 1998 The plant alkaloid emetine has considerable potential as an antitumor agent, but early attempts to develop the compound clinically failed due to unacceptable dose limiting toxicity and poorly reproducible results.
Sasa Dimitrijevic, Ruth Duncan
core +1 more source
Emetine treatment masks initial LTP without affecting long-term stability
, 2011 Applying emetine, a protein synthesis inhibitor, at 20-40μM for 90-120min prior to LTP induction in hippocampal slices from young rats (2-3weeks) and washing it out afterwards revealed a slowly developing potentiation that reached maximum after 20-30min,
Li, Rui, +9 more
core +1 more source
Emetine Regulates the Alternative Splicing of Bcl-x through a Protein Phosphatase 1-Dependent Mechanism [PDF]
, 2007 SummaryExon 2 of the Bcl-x gene undergoes alternative splicing in which the Bcl-xS splice variant promotes apoptosis in contrast to the anti-apoptotic splice variant Bcl-xL.
Yu, Qingming +5 more
core +1 more source
Emetine as an Anti-Cancer Therapeutic in Bladder Cancer [PDF]
, 2015 Bladder cancer is a serious health concern among the older population, as it is responsible for thousands of deaths annually in the United States. Patients that are diagnosed with muscle-invasive disease have a 5-year survival rate of only 20 percent ...
Davidson, Valerie
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CD9 expression rivals IDH mutation as a prognostic marker in glioma: a novel nomogram approach. [PDF]
Front NeurolPurposeGlioma remains a lethal malignancy with limited prognostic biomarkers. This study evaluates the prognostic significance and functional mechanisms of tetraspanin CD9 in glioma to establish its clinical relevance and identify therapeutic strategies ...
Peng Y +5 more
europepmc +2 more sources
Computational Identification of Potential Antiviral Agents Against Monkeypox Virus
Düzce Üniversitesi Bilim ve Teknoloji DergisiThis study introduces a drug repurposing approach for monkeypox virus using molecular docking and molecular dynamics (MD) simulations to screen clinically approved drugs for other diseases. Potential candidates were analyzed with AutoDock software in two
Harun Selvitopi +7 more
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