Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses [PDF]
Pharmaceuticals, 2020 The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat ...
, Peterson Gregory M
exaly +4 more sources
Gene expression profiling before and after internode culture for adventitious shoot formation in ipecac [PDF]
BMC Plant Biology, 2022 Background In ipecac (Carapichea ipecacuanha (Brot.) L. Andersson), adventitious shoots can be induced simply by placing internodal segments on phytohormone-free culture medium.
Karin Okazaki +6 more
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Emetine Is Not Ipecac: Considerations for Its Use as Treatment for SARS-CoV2 [PDF]
Pharmaceuticals, 2020 Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity.
Martin D. Bleasel, Gregory M. Peterson
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Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations [PDF]
Virus ResearchThe emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health.
Viktoriya S. Sidorenko +24 more
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Dual effects of ipecac alkaloids with potent antiviral activity against foot-and-mouth disease virus as replicase inhibitors and direct virucides [PDF]
International Journal of Veterinary Science and MedicineFoot-and-Mouth Disease (FMD) is a contagious, blistering disease caused by the Foot-and-Mouth Disease virus (FMDV), which affects livestock globally. Currently, no commercial antiviral agent is available for effective disease control.
Achiraya Pantanam +6 more
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Cephaeline promotes ferroptosis by targeting NRF2 to exert anti-lung cancer efficacy [PDF]
Pharmaceutical BiologyContext Cephaeline is a natural product isolated from ipecac (Cephaelis ipecacuanha [Brot.] A. Rich. [Rubiaceae]). It exhibits promising anti-lung cancer activity and ferroptosis induction may be a key mechanism for its anti-lung cancer effect.Objectives
Peng Chen +3 more
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Emetine and cephaeline content in plants of Psychotria ipecacuanha in Costa Rica
Revista Colombiana de Química, 2020 The objective of this study was to identify the emetic metabolites in different parts of the P. ipecacuanha, a plant with emetic properties. Partial phytochemical analysis was performed to determine the presence of emetine and cephaeline in leaves, stems
María Catalina Rosales López +2 more
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Molecules, 2015 Ipecac alkaloids are secondary metabolites produced in the medicinal plant Psychotria ipecacuanha. Emetine is the main alkaloid of ipecac and one of the active compounds in syrup of Ipecac with emetic property. Here we evaluated emetine’s potential as an
Ana Luiza Chaves Valadão +6 more
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Angustinine – A New Benzopyridoquinolizine Alkaloid from
Natural Product Communications, 2012 A new benzopyridoquinolizine alkaloid, designated as angustinine (1), was isolated from the root bark of Alangium lamarckii Thwaites, along with the known ipecac alkaloid, emetine.
Mumu Chakraborty, Sibabrata Mukhopadhyay
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Frontiers in Pharmacology, 2017 Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular.
Mohsen Fahradpour +8 more
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