Results 1 to 10 of about 3,849 (112)

Discovery of a Plant Pictet-Spenglerase With R-Stereoselectivity. [PDF]

Angew Chem Int Ed Engl
Strictosidine synthases (STRs) are plant Pictet–Spenglerases catalyzing the coupling of a secoiridoid with tryptamine. All previously characterized strictosidine synthases are strictly S‐selective. Here, we report the discovery of Epi‐STR, an R‐selective STR ortholog from the medicinal plant Pogonopus speciosus.
Morweiser C, Heinicke S, O'Connor SE, Colinas M.   +3 more
europepmc   +3 more sources

Ipecac root extracts and isolated circular peptides differentially suppress inflammatory immune response characterised by proliferation, activation and degranulation capacity of human lymphocytes in vitro. [PDF]

Biomed Pharmacother, 2022
Circular peptides are attractive lead compounds for drug development; this study investigates the immunomodulatory effects of defined root powder extracts and isolated peptides (called cyclotides) from Carapichea ipecacuanha (Brot.) L. Andersson ('ipecac'
Falanga CM, Steinborn C, Muratspahić E, Zimmermann-Klemd AM, Winker M, Krenn L, Huber R, Gruber CW, Gründemann C.   +8 more
europepmc   +2 more sources

Ectopic expression of LONELY GUY7 in epidermis of internodal segments for de novo shoot regeneration without phytohormone treatment in ipecac. [PDF]

Physiol Plant
Abstract In many plant species, the application of exogenous phytohormones is crucial for initiating de novo shoot regeneration. However, ipecac [Carapichea ipecacuanha (Brot) L. Andersson] has a unique ability to develop adventitious shoots on the epidermis of internodal segments without phytohormone treatment.
Okazaki K, Katano W, Shibata K, Asahina M, Koshiba-Takeuchi K, Shimomura K, Umehara M.   +6 more
europepmc   +2 more sources

Emetine, Ipecac, Ipecac Alkaloids and Analogues as Potential Antiviral Agents for Coronaviruses. [PDF]

Pharmaceuticals (Basel), 2020
The COVID-19 coronavirus is currently spreading around the globe with limited treatment options available. This article presents the rationale for potentially using old drugs (emetine, other ipecac alkaloids or analogues) that have been used to treat ...
Bleasel MD, Peterson GM.
europepmc   +3 more sources

RECOVER Guidelines: First Aid for Dogs and Cats. Clinical Guidelines. [PDF]

J Vet Emerg Crit Care (San Antonio)
ABSTRACT Objective To present evidence‐ and consensus‐based guidelines for prehospital first aid in dogs and cats. Design Prioritized clinical questions pertaining to first aid posed in the Population–Intervention–Comparator–Outcome (PICO) format were used to inform systematic literature searches by information specialists, which facilitated extraction
Mandell DC, Thawley VJ, Burkitt-Creedon JM, Fletcher DJ, Boller M, Fausak E.   +5 more
europepmc   +2 more sources

RECOVER Guidelines: First Aid in Dogs and Cats. Evidence and Knowledge Gap Analysis With Treatment Recommendations. [PDF]

J Vet Emerg Crit Care (San Antonio)
ABSTRACT Objective To systematically review the evidence on, to devise clinical recommendations for, and to identify critical knowledge gaps regarding the provision of first aid in dogs and cats. Design Standardized, systematic evaluation of literature pertinent to first aid following Grading of Recommendations, Assessment, Development, and Evaluation ...
Thawley VJ, Mandell DC, Burkitt-Creedon JM, Fletcher DJ, Boller M, Anderson K, Flammer SA, Brown FJL, Donaldson R, Guieu L, Hansen SC, Harris BA, Hart AR, Hewes CA, Hughes JL, Kirchofer KS, Kornya M, Luca GC, Maglaras C, McBride D, Miller VS, Moberly HK, Rey LM, Rhue K, Rudloff E, Scarabelli S, Smith KM, Swor TM.   +27 more
europepmc   +2 more sources

Emetine Is Not Ipecac: Considerations for Its Use as Treatment for SARS-CoV2. [PDF]

Pharmaceuticals (Basel), 2020
Emetine is a potent antiviral that acts on many viruses in the low-nM range, with several studies in animals and humans demonstrating antiviral activity. Historically, emetine was used to treat patients with Spanish influenza, in the last stages of the
Bleasel MD, Peterson GM.
europepmc   +2 more sources

Lectotypification of Callicocca ipecacuanha Brot. and neotypification of Cephaelis acuminata H.Karst., with reference to the drug Ipecac

, 2005
The main pharmacopoeias cite the roots of Cephaelis ipecacuanha (syn. Callicocca ipecacuanha Brot.) together with the roots of Cephaelis acuminata H.Karst.
Thulin, Mats,, Wieringa, Jan, de Boer, Hugo,   +2 more
core   +9 more sources

Ipecac

6.5 x 2.25 x 2.25.
Benzoni T, Gibson J.
europepmc   +1 more source

Emetine dihydrochloride alleviated radiation‐induced lung injury through inhibiting EMT

Journal of Cellular and Molecular Medicine, Volume 27, Issue 23, Page 3839-3850, December 2023., 2023
Abstract Radiation‐induced lung injury (RILI), divided into early radiation pneumonia (RP) and late radiation‐induced pulmonary fibrosis (RIPF), is a common serious disease after clinical chest radiotherapy or nuclear accident, which seriously threatens the life safety of patients.
Xin Wang, Mo Li, Jizhong Yin, Jiayan Fang, Yimeng Ying, Tianxia Ye, Fangxiao Zhang, Shumei Ma, Hongran Qin, Xiaodong Liu   +9 more
wiley   +1 more source