Results 31 to 40 of about 3,486 (152)

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Molecular Oncology, Volume 19, Issue 4, Page 1155-1169, April 2025.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee   +8 more
wiley   +1 more source

An epidemiological snapshot of toxicological exposure in children 12 years of age and younger in Riyadh

Annals of Saudi Medicine, 2019
BACKGROUND: Poisoning among the pediatric population is an important public health concern that is responsible for frequent pediatric emergency department visits and hospital admissions.
Nahar Dakeel Alruwaili, Bachar Halimeh, Mohammed Al-Omar, Badria Alhatali, Ismail Ibrahim Sabie, Mohammed Alsaqoub   +5 more
doaj   +1 more source

Investigation on the Antibacterial and Anti‐T3SS Activity of Traditional Myanmar Medicinal Plants

Evidence-Based Complementary and Alternative Medicine, Volume 2018, Issue 1, 2018., 2018
Myanmar has a rich pool of, but less known, medicinal plants with traditional knowledge. In this study, we aimed to investigate the inhibitory activity of traditional Myanmar medicinal plants against the type III secretion system (T3SS) of Salmonella enterica serovar Typhimurium UK‐1 χ8956 and the intestinal disease‐caused by microbes including S ...
Tianhong Li, Dongdong Zhang, Thaung Naing Oo, Myint Myint San, Aye Mya Mon, Pyae Phyo Hein, Yuehu Wang, Chunhua Lu, Xuefei Yang, Nicola Malafronte   +9 more
wiley   +1 more source

Exposições tóxicas agudas em crianças: um panorama Acute toxic exposure in children: an overview

Jornal de Pediatria, 2005
OBJETIVO: Revisar a literatura das exposições tóxicas em pediatria, excluindo os acidentes por animais peçonhentos. FONTES DE DADOS: Revisão narrativa dos principais trabalhos indexados no MEDLINE, especialmente da última década, incluindo as revisões de
Fábio Bucaretchi, Emílio C. E. Baracat
doaj   +1 more source

Western Anthelmintics in Early Twentieth‐Century China Colonial Practices and Knowledge on “Tropical Diseases” of the In/between**

Berichte zur Wissenschaftsgeschichte, Volume 47, Issue 4, Page 330-351, December 2024.
Abstract Protestant (medical) missionaries were the main proponents of Western medicine in China after the Opium Wars. Several studies have highlighted how they used spectacular surgery as a means of gaining public trust. As well as surgery, they also administered anthelmintic drugs such as santonin as a tool of persuasion and conversion.
Dominik Merdes
wiley   +1 more source

Evaluation of the Antiemetic Effect of Valeriana officinalis Root Extract in Young Chicken

Journal of Medicinal Plants, 2011
Background: In traditional medicine, the roots and rhizomes of Valeriana officinalis (Valerian) have been used to decrease gastrointestinal tract motility in intestinal spasms, colic and gastrointestinal disorders of nervous origin.
H Hosseinzadeh, MR Jaafari, BH Parhiz
doaj  

Tamanhos e posições de explantes e volumes de meio de cultivo na multiplicação de ipeca (Psychotria ipecacuanha (Brot.) Stokes) in vitro Explant sizes and positions and volume of medium of culture on the multiplication of Ipecac (Psychotria ipecacuanha (Brot.) Stokes) in vitro

Ciência e Agrotecnologia, 2004
No presente trabalho, avaliaram-se o efeito do tamanho e posição de explantes na planta de ipeca e diferentes volumes de meio de cultivo na multiplicação "in vitro" de Psychotria ipecacuanha (Brot.) Stokes.
Érika Soares Reis, José Eduardo Brasil Pereira Pinto, Ricardo Monteiro Corrêa, Suzan Kelly Vilela Bertolucci, Osmar Alves Lameira   +4 more
doaj   +1 more source

The translational inhibitor and amnestic agent emetine also suppresses ongoing hippocampal neural activity similarly to other blockers of protein synthesis

Hippocampus, Volume 34, Issue 8, Page 380-392, August 2024.
Abstract The consolidation of memory is thought to ultimately depend on the synthesis of new proteins, since translational inhibitors such as anisomycin and cycloheximide adversely affect the permanence of long‐term memory. However, when applied directly in brain, these agents also profoundly suppress neural activity to an extent that is directly ...
S. Al‐Smadi, A. Padros, G. G. Goss, C. T. Dickson   +3 more
wiley   +1 more source

Clonal diversity and conservation genetics of the medicinal plant Carapichea ipecacuanha (Rubiaceae)

Genetics and Molecular Biology, 2010
The roots of the understorey shrub Carapichea ipecacuanha (ipecac) have medicinal properties, and the uprooting of wild plants has supplied most of the world demand for this species. Although under severe population decline, C.
Luiz Orlando de Oliveira, Bruna Afonso Venturini, Ana Aparecida Bandini Rossi, Saulo Santos Hastenreiter   +3 more
doaj  

Reproductive studies on ipecac (Cephaelis ipecacuanha (Brot.) A. Rich; Rubiaceae): meiotic behavior and pollen viability

Brazilian Journal of Biology
Reproductive studies were carried out on Brazilian accessions of ipecac, Cephaelis ipecacuanha. Meiotic behavior was studied using the squashing technique.
M. M. Souza, E. R. Martins, T. N. S. Pereira, L. O. Oliveira   +3 more
doaj   +1 more source