A target enrichment probe set for resolving phylogenetic relationships in the coffee family, Rubiaceae. [PDF]
Appl Plant Sci, 2023 Abstract Premise Rubiaceae is among the most species‐rich plant families, as well as one of the most morphologically and geographically diverse. Currently available phylogenies have mostly relied on few genomic and plastid loci, as opposed to large‐scale genomic data.
Ball LD +3 more
europepmc +2 more sources
Cyclotide discovery in Gentianales revisited--identification and characterization of cyclic cystine-knot peptides and their phylogenetic distribution in Rubiaceae plants. [PDF]
Biopolymers, 2013 ABSTRACT Cyclotides are a unique class of ribosomally synthesized cysteine‐rich miniproteins characterized by a head‐to‐tail cyclized backbone and three conserved disulfide‐bonds in a knotted arrangement. Originally they were discovered in the coffee‐family plant Oldenlandia affinis (Rubiaceae) and have since been identified in several species of the ...
Koehbach J +12 more
europepmc +2 more sources
Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor. [PDF]
Front Pharmacol, 2017 Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular.
Fahradpour M +6 more
europepmc +3 more sources
Natural Plant Alkaloid (Emetine) Inhibits HIV-1 Replication by Interfering with Reverse Transcriptase Activity [PDF]
Molecules, 2015 Ipecac alkaloids are secondary metabolites produced in the medicinal plant Psychotria ipecacuanha. Emetine is the main alkaloid of ipecac and one of the active compounds in syrup of Ipecac with emetic property. Here we evaluated emetine’s potential as an
Ana Luiza Chaves Valadão +6 more
doaj +2 more sources
Clonal diversity and conservation genetics of the medicinal plant Carapichea ipecacuanha (Rubiaceae) [PDF]
Genetics and Molecular Biology, 2010 The roots of the understorey shrub Carapichea ipecacuanha (ipecac) have medicinal properties, and the uprooting of wild plants has supplied most of the world demand for this species. Although under severe population decline, C.
Luiz Orlando de Oliveira +3 more
doaj +2 more sources
Lead Optimization of Dehydroemetine for Repositioned Use in Malaria. [PDF]
Antimicrob Agents Chemother, 2020 Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel anti-malarial treatments. The anti-amoebic compound, emetine dihydrochloride, has been identified as a potent in-vitro inhibitor of the multi ...
Panwar P +8 more
europepmc +5 more sources
Recent developments on potential new applications of emetine as anti-cancer agent. [PDF]
EXCLI J, 2016 Uzor PF.
europepmc +4 more sources
New Phytologist, Volume 238, Issue 4, Page 1534-1545, May 2023., 2023 Summary Peptide asparaginyl ligases (PALs) are useful tools for precision modifications of proteins and live‐cell surfaces by ligating peptides after Asn/Asp (Asx). They share high sequence and structural similarity to plant legumains that are generally known as asparaginyl endopeptidases (AEPs), thus making it challenging to identify PALs from AEPs ...
Xinya Hemu +8 more
wiley +1 more source
Coevolution as an engine of biodiversity and a cornucopia of ecosystem services
PLANTS, PEOPLE, PLANET, Volume 3, Issue 1, Page 61-73, January 2021., 2021 Coevolutionary processes, which have governed interactions between organisms throughout the history of life, also serve as an engine of ecosystem services for humans. The escalating arms races between plants and herbivores, flowers and pollinators, have generated a cornucopia of foods, raw materials, perfumes, spices, ornamentals, medicines, and drugs.
Robert A. Raguso
wiley +1 more source
BioMed Research International, Volume 2021, Issue 1, 2021., 2021 Dengue remains one of the most serious and widespread mosquito‐borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths.
Muhammad Torequl Islam +16 more
wiley +1 more source