Results 81 to 90 of about 6,696 (158)

In vitro activity of antiamoebic drugs against clinical isolates of Entamoeba histolytica and Entamoeba dispar

Annals of Clinical Microbiology and Antimicrobials, 2004
Background Amoebiasis is a major public health problem in tropical and subtropical countries. Although a number of antiamoebic agents are used for its treatment, yet the susceptibility data on clinical isolates of Entamoeba histolytica and Entamoeba ...
Mahajan Ramesh, Chawla Yogesh, Sehgal Rakesh, Bansal Devendra, Malla Nancy   +4 more
doaj   +1 more source

Emetine myopathy in the rat

, 1976
1 (-)Emetine (0.25-2.0 mg/kg i.p.) was administered to rats for up to 220 days. 2 At doses of 1.0 mg/kg or less, the animals continued to gain weight but more slowly than the untreated control animals.
Harris, J B, Bradley, W G, Johnson, M A, Fewings, J D   +3 more
core   +1 more source

Schematic representations and 3D visualizations of molecular interactions of Emetine with the target proteins.

(A) Schematic depiction of interactions for Emetine with 6LU7, (B) 3D representation of Emetine (grey) interactions with 6LU7 (purple) (C) Schematic depiction of interactions for Emetine with 6LZG and (D) 3D representation of Emetine (grey) interactions ...
Iqra Ahmad (17471892), Haq Nawaz (63419), Sheheryar (12259148), Mohibullah Shah (1590358), Riaz Ullah (5547797), Ke Chen (73307), Amen Shamim (10008107), Essam A. Ali (14000319), Umar Nishan (571108), Gang Wu (23885), Ramsha Yamin (17768636), Zainab Jahangir (17768639)   +11 more
core   +1 more source

Metabolite profiling and computational analysis of alkaloids of Carica papaya L. var. California leaves ethanol extract as a drug candidate

Pharmaciana
Papaya (Carica papaya L.) var. California leaves are widely used as traditional medicine. Several scientific studies have demonstrated that papaya leaves possess biological and pharmacological properties, with potential to be developed into a ...
Martina Kurnia Rohmah, A’yunil Hisbiyah, Tutiek Purwanti   +2 more
doaj   +1 more source

Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry

, 2018
The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need.
Yi Zhou, Dushyantha T. Jayaweera, Huang, Wenwei, Yuying Wu, Ruili Huang, Pinto, Antonella, Guoli Ming, Farhy, Chen, Xu, Miao, Xin Hu, Anil Mathew Tharappel, Khalida Shamim, Anton Simeonov, Hongjun Song, Antonella Pinto, Billy Lu, Wei Sun, Shamim, Khalida, Wu, Yuying, Zheng, Wei, Gorshkov, Kirill, Xiangguo Qiu, Shiryaev, Sergey A, He, Shihua, Alexey V. Terskikh, Sun, Wei, Huang, Chun-Teng, Qiu, Xiangguo, Lee, Emily M, Cheng, Yu-Shan, Heng Zhu, Jayaweera, Dushyantha T, Zhu, Wenjun, Martínez-Romero, Carles, Tang, Hengli, Wenwei Huang, Lu, Billy, Xia, Menghang, Emily M Lee, Zirui Zhang, Menghang Xia, Simeonov, Anton, Wenjun Zhu, Guang Song, Adolfo García-Sastre, Hu, Xin, Song, Hongjun, Miao Xu, Yu-Shan Cheng, Huang, Ruili, Zhang, Zirui, García-Sastre, Adolfo, Preston, Richard A, Yang, Shu, Tharappel, Anil Mathew, Wei Zheng, Shihua He, Kirill Gorshkov, Terskikh, Alexey V, Sergey A. Shiryaev, Chun-Teng Huang, Song, Guang, Carles Martínez-Romero, Hengli Tang, Ming, Guoli, Zhu, Heng, Zhou, Yi, Chen Farhy, Shu Yang, Richard A. Preston   +69 more
core   +1 more source

Repurposed drugs in combinations exert additive anti-chikungunya virus activity: an in-vitro study

Virology Journal
Chikungunya virus (CHIKV) infection causes chikungunya, a viral disease that currently has no specific antiviral treatment. Several repurposed drug candidates have been investigated for the treatment of the disease.
Kusuma Sai Davuluri, Rajnandini Ghanghav, Gunwant Ahire, Mahadeo Kakade, Sarah Cherian, Kalichamy Alagarasu, Deepti Parashar   +6 more
doaj   +1 more source

Formal Total Synthesis of (−)-Emetine Using Catalytic Asymmetric Allylation of Cyclic Imines as a Key Step

, 2016
Catalytic asymmetric allylation of 3,4-dihydro-6,7-dimethoxyisoquinoline was carried out using allyltrimethoxysilane in the presence of Cu(I) and tol-BINAP. The allyl adduct thus obtained was transformed to a chiral synthetic intermediate for (−)-emetine
Takashi Itoh (1780201), Michiko Miyazaki (693760), Hiromi Fukuoka (2236465), Akio Ohsawa (2643946), Kazuhiro Nagata (132457)   +4 more
core   +1 more source

Design, Synthesis, and Evaluation of pH-Dependent Hydrolyzable Emetine Analogues as Treatment for Prostate Cancer

, 2016
The N-2′ position of the natural product emetine has been derivatized to thiourea, urea, sulfonamide, dithiocarbamate, carbamate, and pH responsive hydrolyzable amide analogues.
Bernard Kwabi-Addo (45546), Samuel R. Denmeade (273180), Marc D. Rosen (2044066), Oladapo Bakare (2044063), Emmanuel S. Akinboye (2044060)   +4 more
core   +1 more source

A Trial With Emetine For Treatment of Lymphoma

Eurasian Journal of Medicine, 2019
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Aydoğan Albayrak, M.Celal Apaydın
doaj  

Combinatory classification for emetine with existing antimalarials using the CalcuSyn analysis method.

, 2017
Combinatory classification for emetine with existing antimalarials using the CalcuSyn analysis method.
Jon Deakin (3813211), May Rajab (3813214), Holly Matthews (242183), Maryam Idris-Usman (3813217), Niroshini J. Nirmalan (1275435)   +4 more
core   +1 more source