Results 61 to 70 of about 6,696 (158)

New drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing. [PDF]

PLoS ONE, 2018
Atypical meningiomas are common central nervous system neoplasms with high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical excision and radiotherapy remains the mainstay therapy but medical treatments are limited. We
Zsolt Zador, Andrew T King, Nophar Geifman   +2 more
doaj   +1 more source

Isolation of 3β‐Hydroxylupenal From Ceriops decandra Leaves and Evaluation of In Vivo Analgesic and Anti‐Inflammatory Effects Supported by Molecular Docking

BioMed Research International, Volume 2026, Issue 1, 2026.
Ceriops decandra (Griff.) Ding Hou, locally known as “Goran” in Bangladesh, is a recognized mangrove plant of the Sundarbans. Coastal communities living in tidal areas traditionally use this plant for treating various ailments. While numerous biological activities of this plant have been reported, its leaves of Bangladeshi origin have not been ...
Asef Raj, Sania Ashrafi, Md. Sakhawat Hossain, Md. Saiful Islam, Muhammad Abdullah Al-Mansur, Abu Bin Ihsan, Md. Ruhul Kuddus, Firoj Ahmed, Baisakhi Banerjee   +8 more
wiley   +1 more source

Toxicity and tissue distribution studies on the hydrochloride, bismuth iodide complex and a resinate of emetine

, 1964
The hydrochloride, the bismuth iodide complex and a resinate of emetine have been compared on mice, cats and dogs for toxicity, on cats for emetic activity and on rats for distribution of emetine in the tissues.
B Davis, K J Child, E G Tomich, M G Dodds   +3 more
core   +1 more source

Antibacterial Activity of Zanthoxylum chalybeum, Aloe deserti, and Zanthoxylum usambarense

BioMed Research International, Volume 2026, Issue 1, 2026.
Various Gram‐positive and Gram‐negative enteric pathogens are responsible for bacterial gastroenteritis, and this condition is commonly treated with antibiotics. But, the growing prevalence of antimicrobial resistance and drug‐associated toxicities has diminished the effectiveness of conventional drugs, prompting the need for alternative remedies ...
Stephen Mugambi Maithulia, Careen Ihazano Chumba, John Muthini Maingi, David Ng’ang’a Mburu, Eliud Nyaga Mwaniki Njagi, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

GI myoelectric activity recorded from segment 3 during emetine infusion.

, 2019
A) Example of a 70 min filtered and downsampled GI myoelectric recorded from segment 3 of an anesthetized ferret during emetine infusion trials. Emetine induced retch (yellow line) is observed approximately 28 min post emetine infusion (blue line).
Shuyan Zhai (4245967), Derek M. Miller (7517441), Stephanie Fulton (350693), John Ogren (3132240), Ameya C. Nanivadekar (7517438), Charles C. Horn (7517456), Liane Wong (7517444), Bryan McLaughlin (4370257), Girish Chitnis (7517447), Bill J. Yates (7517453), Lee E. Fisher (7517450)   +10 more
core   +1 more source

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

Mechanisms of antiviral action and toxicities of ipecac alkaloids: Emetine and dehydroemetine exhibit anti-coronaviral activities at non-cardiotoxic concentrations

Virus Research
The emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health.
Viktoriya S. Sidorenko, Ira Cohen, Kunchok Dorjee, Conceição A. Minetti, David P. Remeta, Junyuan Gao, Irina Potapova, Hong Zhan Wang, Janet Hearing, Wan-Yi Yen, Hwan Keun Kim, Keiji Hashimoto, Masaaki Moriya, Kathleen G. Dickman, Xingyu Yin, Miguel Garcia-Diaz, Rajesh Chennamshetti, Radha Bonala, Francis Johnson, Amanda L. Waldeck, Ramesh Gupta, Chaoping Li, Kenneth J. Breslauer, Arthur P. Grollman, Thomas A. Rosenquist   +24 more
doaj   +1 more source

Inhibitors of RNA and protein synthesis cause Glut4 translocation and increase glucose uptake in adipocytes

Scientific Reports, 2022
Insulin stimulates glucose uptake in adipocytes by triggering translocation of glucose transporter 4-containg vesicles to the plasma membrane. Under basal conditions, these vesicles (IRVs for insulin-responsive vesicles) are retained inside the cell via ...
A. B. Meriin, N. Zaarur, J. S. Bogan, K. V. Kandror   +3 more
doaj   +1 more source

Alkaloids (emetine and cephalin) production – affected by full sunlight stress in Carapichea ipecacuanha

, 2023
This study evaluated the responses of Carapichea ipecacuanha to sunlight stress-induced changes in the electron transport chain and its extended effects on alkaloid production (emetine and cephalin). The treatments consisted of: (i).
Cristina Moll Hüther (14614357), Daniela Marques Correia (14614369), Fernanda Reinert (6072074), Carlos Rodrigues Pereira (5890094), Ramonn Diego Barros de Almeida (14614366), Wilson da Costa Santos (14614363), Ana Claudia Langaro (4703986), Glauce Christian Alves Duarte (14614372), Fernando de Carvalho da Silva (14614360), Julia Ramos de Oliveira (14614375), Jóice Azeredo Silva (14614378), Camila Ferreira de Pinho (14614381), Junior Borella (5861813), Vitor Francisco Ferreira (9443472), Thelma de Barros Machado (5770706)   +14 more
core   +1 more source

Plant Hormone Cytokinin as Aggregation Modulator of Gelsolin Amyloidosis

Journal of Peptide Science, Volume 31, Issue 10, October 2025.
Gelsolin peptides form amyloids, and aggregation is accelerated by a single point mutation. The gelsolin amyloids can be inhibited using plant hormones. ABSTRACT Amyloidosis, a self‐assembly of proteins or peptides, is associated with numerous degenerative diseases, such as gelsolin amyloidosis, which remain without a cure. Gelsolin protein is an actin‐
Dev Seneviratne, Naomi Stock, Tyra Lewis, R. J. Neil Emery, Sanela Martic   +4 more
wiley   +1 more source