Results 61 to 70 of about 5,579 (176)
Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry
ChemMedChem, Volume 20, Issue 18, September 25, 2025.This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Sadık Hüseyin Cemali +7 more
wiley +1 more source
Targeting the Hippo/YAP Pathway: A Promising Approach for Cancer Therapy and Beyond
MedComm, Volume 6, Issue 9, September 2025.The potential of natural compounds to modulate the Hippo/YAP signaling pathway, a critical regulator of cell proliferation, differentiation, and survival, is explored. Dysregulation of this pathway is associated with various cancers, making it a target for therapeutic intervention.
Rajni Bala +13 more
wiley +1 more source
Frontiers in Pharmacology, 2020 The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public health.
Zhonglei Wang, Zhonglei Wang, Liyan Yang
doaj +1 more source
Angustinine – A New Benzopyridoquinolizine Alkaloid from
Natural Product Communications, 2012 A new benzopyridoquinolizine alkaloid, designated as angustinine (1), was isolated from the root bark of Alangium lamarckii Thwaites, along with the known ipecac alkaloid, emetine.
Mumu Chakraborty, Sibabrata Mukhopadhyay
doaj +1 more source
In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone
Drug Development Research, Volume 86, Issue 5, August 2025.ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp +4 more
wiley +1 more source
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source
New Diagnostic and Therapeutic Targets for Spinal Cord Injury: GRN Gene
Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.ABSTRACT Spinal cord injury (SCI) is a severe disabling disease due to the poor self‐healing of the central nervous system. Studies showed that many N6‐methyladenosine (m6A) RNA methylation profiles are hypomethylated after SCI, which are related to neural regeneration and different m6A marker genes.
Han Ding +6 more
wiley +1 more source
Annals of Clinical Microbiology and Antimicrobials, 2004 Background Amoebiasis is a major public health problem in tropical and subtropical countries. Although a number of antiamoebic agents are used for its treatment, yet the susceptibility data on clinical isolates of Entamoeba histolytica and Entamoeba ...
Mahajan Ramesh +4 more
doaj +1 more source
Computational Identification of Potential Antiviral Agents Against Monkeypox Virus
Düzce Üniversitesi Bilim ve Teknoloji DergisiThis study introduces a drug repurposing approach for monkeypox virus using molecular docking and molecular dynamics (MD) simulations to screen clinically approved drugs for other diseases. Potential candidates were analyzed with AutoDock software in two
Mehmet Enes Arslan +7 more
doaj +1 more source
THE EFFECTS OF EMETINE ON THE HEART [PDF]
Heart, 1945 J D, COTTRELL, G W, HAYWARD
openaire +3 more sources